R
Richard T. Mayer
Researcher at Agricultural Research Service
Publications - 137
Citations - 9140
Richard T. Mayer is an academic researcher from Agricultural Research Service. The author has contributed to research in topics: Diaprepes abbreviatus & Chitinase. The author has an hindex of 40, co-authored 137 publications receiving 8986 citations. Previous affiliations of Richard T. Mayer include University of Oulu & United States Department of Agriculture.
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Journal Article
Ethoxyresorufin: direct fluorimetric assay of a microsomal o-dealkylation which is preferentially inducible by 3-methylcholanthrene
M. Danny Burke,Richard T. Mayer +1 more
TL;DR: Liver microsomes from rat and hamster O-deethylated ethoxyresorufin to resoruf in (7-hydroxyphenoxazone) in an NADPH-and oxygen-dependent reaction involving the flavoprotein.
Journal ArticleDOI
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
M.D. Burke,Stephanie Thompson,Clifford R. Elcombe,James R. Halpert,T Haaparanta,Richard T. Mayer +5 more
TL;DR: It is suggested that the use of some or all of these homologous phenoxazone ethers will provide both a simple routine test for the characterization of several types of inducing agents and a powerful tool for investigating the biochemical basis for cyt.
Journal ArticleDOI
Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat.
Ronald A. Lubet,Richard T. Mayer,John W. Cameron,Raymond W. Nims,M. Danny Burke,Thomas Wolff,F. Peter Guengerich +6 more
TL;DR: The O-dealkylation of pentoxyresorufin by rat liver microsomes was examined and it was observed that this activity, in microsome for Aroclor-pretreated rats, was dependent on O2 and was inhibited by metyrapone and SKF 525-A, indicative of cytochrome P-450 mediation in the reaction.
Book ChapterDOI
[39] Direct fluorometric methods for measuring mexed-function oxidase activity
TL;DR: This chapter focuses on the direct fluorometric methods for measuring mixed-function oxidase activity, and two fluorescent assays are encapsulated in this chapter.
Journal ArticleDOI
Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers (alkoxyresorufins).
M. Danny Burke,Richard T. Mayer +1 more
TL;DR: The metabolism and cytochrome P-450-binding of phenoxazone and a homologous series of its n-alkyl ethers was studied in hepatic microsomes of control, phenobarbitone- pretreated (PB) and 3-methylcholanthrene-pretreated (3MC) C57/BL10 mice, and intermicrosomal differences were interpreted as reflecting the different metabolic specificities of variant forms of cyto chrome P- 450.