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Rick J. Offerman

Bio: Rick J. Offerman is an academic researcher from University of Florida. The author has contributed to research in topics: Reactivity (chemistry) & Catalysis. The author has an hindex of 7, co-authored 12 publications receiving 232 citations.

Papers
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Journal ArticleDOI
01 Jul 1989-Langmuir
TL;DR: Etude et synthese de nombreux derives de la pyridine (sels de pyridinium, oxydes, betaine) pour leur utilisation comme revetement de microcapteur.
Abstract: Etude et synthese de nombreux derives de la pyridine (sels de pyridinium, oxydes, betaine) pour leur utilisation comme revetement de microcapteur

106 citations

Journal ArticleDOI
TL;DR: In this paper, an efficient synthesis of 2-n-dodecylthio-4-phenylthiomethyl-1,3,4-thiadiazole-5-thione is described.

34 citations

Journal ArticleDOI
TL;DR: In this paper, the 1-imidoylbenzotriazol-1-yl enamines were attacked by Grignard reagents at the carbon atom and also at the benzotitriazolyl N-2 and N-3 atoms leading to complex reaction mixtures.
Abstract: Grignard reagents attack 1-imidoylbenzotriazoles at the imidoyl carbon atom and also at the benzotriazolyl N-2 and N-3 atoms leading to complex reaction mixtures, the composition of which allowed identification of the main reaction paths. Mechanisms are discussed. Previous examples of nucleophilic attack on pyridine-like nitrogen atoms are reviewed. The 1-imidoylbenzotriazoles were prepared from amides with benzotriazole and phosphoryl chloride. Amides derived from secondary amines give α-(benzotriazol-1-yl) enamines.

28 citations

Journal ArticleDOI
TL;DR: In this paper, the Wittig reaction was used to synthesize 1-(1-chloroalkyl)benzotriazoles and aldehydes via Wittig reactions.
Abstract: The title compounds are prepared either (A) from 1-(1-chloroalkyl)benzotriazoles and aldehydes via Wittig reaction or (B) from 1-[1,1-bis(trimethylsilyl)alkyl]benzotriazoles by alkylative desilylation by fluoride ion in the presence of a carbonyl compound (in one instance by lithiation of the silyl compound and subsequent reaction with a carbonyl electrophile) via a Peterson olefination. The methods are applicable to both alkyl and aryl ketones and to aldehydes, with method (B) giving the highest yields.

21 citations

Journal ArticleDOI
TL;DR: This review covers various aspects of microsensor technology with which the authors have been associated in their research program, and deals with the development of new coatings for use on surface acoustic wave devices for both resistance and frequency-based measurements.
Abstract: This review covers various aspects of microsensor technology with which we have been associated in our research program. Current work deals with the development of new coatings for use on surface acoustic wave (SAW) devices for both resistance and frequency-based measurements. The microsensor area is currently a small but rapidly expanding field that involves diverse disciplines, including synthetic and polymer chemistry, analytical chemistry, surface science, computer science, and electronic engineering. We have attempted to assist the reader by describing various other facets while highlighting the development of new microsensor coatings. These facets include the way in which the synthetic chemistry is guided by requirements of coating technology and surface science and notes on the use of sophisticated electronic devices and data manipulation techniques to evaluate the compounds synthesized.

15 citations


Cited by
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Journal ArticleDOI
15 Nov 2006-Langmuir
TL;DR: A range of film morphologies based on the film deposition conditions are presented here to establish an optimized method of APTES film formation.
Abstract: Thin films of 3-aminopropyltriethoxysilane (APTES) are commonly used to promote adhesion between silica substrates and organic or metallic materials with applications ranging from advanced composites to biomolecular lab-on-a-chip. Unfortunately, there is confusion as to which reaction conditions will result in consistently aminated surfaces. A wide range of conflicting experimental methods are used with researchers often assuming the creation of smooth self-assembled monolayers. A range of film morphologies based on the film deposition conditions are presented here to establish an optimized method of APTES film formation. The effect of reaction temperature, solution concentration, and reaction time on the structure and morphology was studied for the system of APTES on silica. Three basic morphologies were observed: smooth thin film, smooth thick film, and roughened thick film.

668 citations

Journal ArticleDOI
28 Oct 2006-Langmuir
TL;DR: It is demonstrated that zwitterionic polymers highly resist nonspecific protein adsorption and cell adhesion and provides an effective method to modify glass slides or other oxide surfaces to achieve superlow fouling.
Abstract: This work describes the superlow fouling properties of glass slides grafted with zwitterionic polymers to highly resist the adsorption of proteins and the adhesion of mammalian cells. Glass slides were first silanized using 2-bromo-2-methyl-N-3-[(triethoxysilyl)propyl]propanamide (BrTMOS). Two zwitterionic polymers, poly(sulfobetaine methacrylate) (polySBMA) and poly(carboxybetaine methacrylate) (polyCBMA), were then grafted from the silanized glass substrates using the atom-transfer radical polymerization (ATRP) method. X-ray photoelectron spectroscopy (XPS) was used to analyze the surfaces of the silanized glass substrates and the substrates grafted with the polymers. An enzyme-linked immonosobrbent assay (ELISA) using polyclonal antibodies was used to measure fibrinogen adsorption on these surfaces. The surfaces with polySBMA or polyCBMA layers were shown to reduce fibrinogen adsorption to a level comparable with that of adsorption on poly(ethylene glycol)-like films. Bovine aortic endothelial cells (B...

653 citations

Journal ArticleDOI
Lynn W. Jelinski1
TL;DR: In this article, Bovey and Jelinsky proposed a two-dimensional nuclear magnetic resonance spectroscopy (2D NMS) method, which is based on the Coupling of Nuclear Spins (CNS).
Abstract: Fundamental Principles. L.W. Jelinsky, Experimental Methods. The Chemical Shift. Coupling of Nuclear Spins. Nuclear Relaxation and Chemical Rate Processes. P.A. Mirau and F.A. Bovey, Two-Dimensional Nuclear Magnetic Resonance Spectroscopy. Macromolecules. NMR of Solids. F.A. Bovey, L.W. Jelinsky, P.A. Mirau, Special Topics. Appendixes. Author Index. Subject Index.

525 citations

Journal ArticleDOI
18 Feb 1998-Langmuir
TL;DR: In this article, a Si−C bond is formed on a silicon(100) surface by reaction of a 1-alkene with the hydrogen-terminated silicon surface, and the monolayers have been analyzed by infrared spectroscopy, X-ray reflectivity, and water contact angle measurements.
Abstract: Monolayers that are bonded via a covalent Si−C bond are prepared on a silicon(100) surface by reaction of a 1-alkene with the hydrogen-terminated silicon surface. The monolayers have been analyzed by infrared spectroscopy, X-ray reflectivity, and water contact angle measurements and display a remarkably high thermal stability. The reaction also works well for ω-functionalized 1-alkenes, provided that the functional group is properly protected. After formation of the monolayer, the protecting group can be easily removed without noticeable disturbance of the monolayer integrity, and the now reactive sites at the monolayer can be used for further functionalization, as has been shown in the case of ester-protected alcohol and carboxylic acids. Functional groups that are too close to the alkene moiety interfere with monolayer formation and yield disordered monolayers.

475 citations

Journal ArticleDOI
TL;DR: Hydrogen-terminated Si(111) surfaces are modified by attachment of oligodeoxynucleotides and characterized with respect to DNA surface density, chemical stability, and DNA hybridization binding specificity, providing an avenue for the development of devices in which the exquisite binding specificity of biomolecular recognition is directly coupled to semiconductor devices.
Abstract: Hydrogen-terminated Si(111) surfaces are modified by attachment of oligodeoxynucleotides and characterized with respect to DNA surface density, chemical stability, and DNA hybridization binding specificity. Surface functionalization employs the reaction of ω-unsaturated alkyl esters with the Si(111) surface using UV irradiation. Cleavage of the ester using potassium tert-butoxide yields a carboxyl-modified surface, which serves as a substrate for the attachment of DNA by means of an electrostatically adsorbed layer of polylysine and attachment of thiol-modified DNA using a heterobifunctional cross-linker. The resultant DNA-modified surfaces are shown to exhibit excellent specificity and chemical stability under the conditions of DNA hybridization. This work provides an avenue for the development of devices in which the exquisite binding specificity of biomolecular recognition is directly coupled to semiconductor devices.

425 citations