Rishikesh M. Sawant

TL;DR: To develop targeted pharmaceutical carriers additionally capable of responding to certain local stimuli, such as decreased pH values in tumors or infarcts, targeted long-circulating PEGylated liposomes and PEG-phosphatidylethanolamine-based micelles have been prepared with several functions.

TL;DR: PCL-containing PEG(2000)-PE/TPGS micelles were stable in vitro under various conditions modeling the physiological ones, in particular, at low pH values and in the presence of bile acids, which is especially important for their possible oral administration.

TL;DR: Stable nanocolloids of insoluble drugs with very high drug content can be easily and reproducibly prepared through the application of the layer-by-layer (LbL) technology, alternate adsorption of oppositely charged polyelectrolytes on the surface of drug nanoparticles produced by ultrasonication of larger drug crystals.

TL;DR: Drug-loaded mixed micelles and mAb 2C5-immunomicelles demonstrated significantly higher in vitro cytotoxicity than free drug against various cancer cell lines.

TL;DR: It is demonstrated that Gd-containing liposomes can be additionally modified with the monoclonal anticancer antibodies possessing the nucleosome(NS)-restricted specificity via the PEG spacer.