R
Rob Knight
Researcher at University of California, San Diego
Publications - 1188
Citations - 322479
Rob Knight is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Microbiome & Biology. The author has an hindex of 201, co-authored 1061 publications receiving 253207 citations. Previous affiliations of Rob Knight include Anschutz Medical Campus & University of Sydney.
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Journal ArticleDOI
Leukotriene B4-receptor-1 mediated host response shapes gut microbiota and controls colon tumor progression.
Venkatakrishna R. Jala,Paramahamsa Maturu,Sobha R. Bodduluri,Elangovan Krishnan,Steven P. Mathis,Krishnaprasad Subbarao,Min Wang,Alfred B. Jenson,Mary Proctor,Eric C. Rouchka,Rob Knight,Bodduluri Haribabu +11 more
TL;DR: A novel interplay between the Toll-like receptor mediated microbial sensing mechanisms and BLT1-mediated host response in the control of colon tumor development is identified.
Journal ArticleDOI
Multiple-Disease Detection and Classification across Cohorts via Microbiome Search
Xiaoquan Su,Gongchao Jing,Zheng Sun,Lu Liu,Zhenjiang Xu,Daniel McDonald,Zengbin Wang,Hong-Lei Wang,Antonio Gonzalez,Yufeng Zhang,Shi Huang,Gavin A. Huttley,Rob Knight,Jian Xu +13 more
TL;DR: This strategy’s precision, sensitivity, and speed outperform model-based approaches, and it is more robust to platform heterogeneity and to contamination in 16S rRNA gene amplicon data sets.
Posted ContentDOI
A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV-2
Daniel J. Brogan,Duverney Chaverra-Rodriguez,Calvin P. Lin,Andrea L. Smidler,Ting Yang,Lenissa M. Alcantara,Igor Antoshechkin,Junru Liu,Robyn R. Raban,Pedro Belda-Ferre,Rob Knight,Elizabeth A. Komives,Omar S. Akbari +12 more
TL;DR: Sensitive Enzymatic Nucleic-acid Sequence Reporter robustly detects SARS-CoV-2 sequences in both synthetic and patient-derived samples by lateral flow and fluorescence, thus expanding the available point-of-care diagnostics to combat current and future pandemics.
Posted ContentDOI
OGUs enable effective, phylogeny-aware analysis of even shallow metagenome community structures
Qiyun Zhu,Qiyun Zhu,Shi Huang,Shi Huang,Antonio Gonzalez,McGrath I,McGrath I,Daniel McDonald,Niina Haiminen,George Armstrong,George Armstrong,Yoshiki Vázquez-Baeza,Yu J,Kuczynski J,Sepich-Poore Gd,Austin D. Swafford,Das P,Das P,Justin P. Shaffer,Lejzerowicz F,Lejzerowicz F,Pedro Belda-Ferre,Aki S. Havulinna,Aki S. Havulinna,Guillaume Méric,Guillaume Méric,Teemu J. Niiranen,Teemu J. Niiranen,Teemu J. Niiranen,Leo Lahti,Salomaa,Hyun-Chul Kim,Miten Jain,Michael Inouye,Michael Inouye,Jack A. Gilbert,Jack A. Gilbert,Rob Knight +37 more
TL;DR: In this article, the authors introduce the Operational Genomic Unit (OGU), a metagenome analysis strategy that directly exploits sequence alignment hits to individual reference genomes as the minimum unit for assessing the diversity of microbial communities and their relevance to environmental factors.
Journal ArticleDOI
The microbiome and prostate cancer
Juan Javier-Desloges,Rana R. McKay,Austin D. Swafford,Gregory D. Sepich-Poore,Rob Knight,J. Kellogg Parsons +5 more
TL;DR: There is growing evidence that the human microbiome is involved in development and treatment of many human diseases, including prostate cancer as discussed by the authors, and there are several potential pathways for microbiome-based mechanisms for the development of prostate cancer.