R
Rob M. van Dam
Researcher at National University of Singapore
Publications - 401
Citations - 46736
Rob M. van Dam is an academic researcher from National University of Singapore. The author has contributed to research in topics: Population & Type 2 diabetes. The author has an hindex of 99, co-authored 362 publications receiving 38939 citations. Previous affiliations of Rob M. van Dam include University Health System & Brigham and Women's Hospital.
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Journal ArticleDOI
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew P. Morris,Benjamin F. Voight,Benjamin F. Voight,Tanya M. Teslovich,Teresa Ferreira,Ayellet V. Segrè,Ayellet V. Segrè,Valgerdur Steinthorsdottir,Rona J. Strawbridge,Hassan Khan,Harald Grallert,Anubha Mahajan,Inga Prokopenko,Hyun Min Kang,Christian Dina,Tõnu Esko,Ross M. Fraser,Stavroula Kanoni,Ashok Kumar,Vasiliki Lagou,Claudia Langenberg,Jian'an Luan,Cecilia M. Lindgren,Martina Müller-Nurasyid,Sonali Pechlivanis,N. William Rayner,Laura J. Scott,S Wiltshire,Loic Yengo,Leena Kinnunen,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Soumya Raychaudhuri,Soumya Raychaudhuri,Andrew D. Johnson,Antigone S. Dimas,Antigone S. Dimas,Antigone S. Dimas,Ruth J. F. Loos,Sailaja Vedantam,Sailaja Vedantam,Han Chen,Jose C. Florez,Jose C. Florez,Caroline S. Fox,Caroline S. Fox,Ching-Ti Liu,Denis Rybin,David Couper,Wen Hong L. Kao,Man Li,Marilyn C. Cornelis,Peter Kraft,Qi Sun,Rob M. van Dam,Rob M. van Dam,Heather M. Stringham,Peter S. Chines,Krista Fischer,Pierre Fontanillas,Oddgeir L. Holmen,Sarah E. Hunt,Anne U. Jackson,Augustine Kong,Robert W. Lawrence,Julia Meyer,John R. B. Perry,John R. B. Perry,Carl G. P. Platou,Simon C. Potter,Emil Rehnberg,Neil Robertson,Suthesh Sivapalaratnam,Alena Stančáková,Kathleen Stirrups,Gudmar Thorleifsson,Emmi Tikkanen,Emmi Tikkanen,Andrew R. Wood,Peter Almgren,Mustafa Atalay,Rafn Benediktsson,Lori L. Bonnycastle,Noël P. Burtt,Jason Carey,Guillaume Charpentier,Andrew Crenshaw,Alex S. F. Doney,Mozhgan Dorkhan,Sarah Edkins,Valur Emilsson,Elodie Eury,Tom Forsén,Karl Gertow,Bruna Gigante,George B. Grant,Christopher J. Groves,Candace Guiducci,Christian Herder,Astradur B. Hreidarsson,Jennie Hui,Jennie Hui,Alan James,Alan James,Anna Jonsson,Wolfgang Rathmann,Norman Klopp,Jasmina Kravic,Kaarel Krjutškov,Cordelia Langford,Karin Leander,Eero Lindholm,Stéphane Lobbens,Satu Männistö,Ghazala Mirza,Thomas W. Mühleisen,Bill Musk,Bill Musk,Melissa Parkin,Loukianos S. Rallidis,Jouko Saramies,Bengt Sennblad,Sonia Shah,Gunnar Sigurðsson,Angela Silveira,Gerald Steinbach,Barbara Thorand,Joseph Trakalo,Fabrizio Veglia,Roman Wennauer,Wendy Winckler,Delilah Zabaneh,Harry Campbell,Cornelia M. van Duijn,André G. Uitterlinden,Albert Hofman,Eric J.G. Sijbrands,Gonçalo R. Abecasis,Katharine R. Owen,Eleftheria Zeggini,Mieke D. Trip,Nita G. Forouhi,Ann-Christine Syvänen,Johan G. Eriksson,Johan G. Eriksson,Leena Peltonen,Markus M. Nöthen,Beverley Balkau,Colin N. A. Palmer,Valeriya Lyssenko,Tiinamaija Tuomi,Bo Isomaa,David J. Hunter,Lu Qi,Alan R. Shuldiner,Alan R. Shuldiner,Michael Roden,Inês Barroso,Tom Wilsgaard,John Beilby,John Beilby,Kees Hovingh,Jackie F. Price,James F. Wilson,Rainer Rauramaa,Timo A. Lakka,Lars Lind,George Dedoussis,Inger Njølstad,Nancy L. Pedersen,Kay-Tee Khaw,Nicholas J. Wareham,Sirkka Keinänen-Kiukaanniemi,Timo Saaristo,Eeva Korpi-Hyövälti,Juha Saltevo,Markku Laakso,Johanna Kuusisto,Andres Metspalu,Francis S. Collins,Karen L. Mohlke,Richard N. Bergman,Jaakko Tuomilehto,Bernhard O. Boehm,Christian Gieger,Kristian Hveem,Stéphane Cauchi,Philippe Froguel,Philippe Froguel,Damiano Baldassarre,Elena Tremoli,Steve E. Humphries,Danish Saleheen,John Danesh,Erik Ingelsson,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Veikko Salomaa,Raimund Erbel,Karl-Heinz Jöckel,Susanne Moebus,Annette Peters,Thomas Illig,Ulf de Faire,Anders Hamsten,Andrew D. Morris,Peter Donnelly,Timothy M. Frayling,Andrew T. Hattersley,Eric Boerwinkle,Eric Boerwinkle,Olle Melander,Sekar Kathiresan,Sekar Kathiresan,Peter M. Nilsson,Panos Deloukas,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Leif Groop,Kari Stefansson,Kari Stefansson,Frank B. Hu,James S. Pankow,Josée Dupuis,Josée Dupuis,James B. Meigs,James B. Meigs,David Altshuler,David Altshuler,Michael Boehnke,Mark I. McCarthy +232 more
TL;DR: This article conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases and 114,981 controls, overwhelmingly of European descent, and identified ten previously unreported T2D susceptibility loci, including two showing sex-differentiated association.
Journal ArticleDOI
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J. Willer,Soumya Raychaudhuri,Soumya Raychaudhuri,Soumya Raychaudhuri,Steve McCarroll,Steve McCarroll,Claudia Langenberg,Oliver Hofmann,Josée Dupuis,Lu Qi,Lu Qi,Ayellet V. Segrè,Ayellet V. Segrè,Mandy van Hoek,Pau Navarro,Kristin Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,N P Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabe Crawford,Alex S. F. Doney,Katherine S. Elliott,Amanda F. Elliott,Amanda F. Elliott,Michael R. Erdos,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Todd Green,Simon J. Griffin,Christopher J. Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U. Jackson,Paul Johnson,Torben Jørgensen,Torben Jørgensen,Wen H. L. Kao,Norman Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Michel Marre,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,Peter M. Nilsson,Katharine R. Owen,Felicity Payne,John R. B. Perry,Ann-Kristin Petersen,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Inga Prokopenko,Wolfgang Rathmann,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,Richa Saxena,Beverley M. Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,Rob M. van Dam,Timon W. van Haeften,Thijs T. W. van Herpt,Jana V. van Vliet-Ostaptchouk,G. Bragi Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,Karen L. Mohlke,Andrew D. Morris,Colin N. A. Palmer,Peter P. Pramstaller,Igor Rudan,Igor Rudan,Eric J.G. Sijbrands,Lincoln Stein,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Mark Walker,Nicholas J. Wareham,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,H-Erich Wichmann,Inês Barroso,Jose C. Florez,Timothy M. Frayling,Leif Groop,Leif Groop,Robert Sladek,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,James F. Wilson,Thomas Illig,Philippe Froguel,Philippe Froguel,Cornelia M. van Duijn,Kari Stefansson,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy +183 more
TL;DR: By combining genome-wide association data from 8,130 individuals with type 2 diabetes and 38,987 controls of European descent and following up previously unidentified meta-analysis signals, 12 new T2D association signals are identified with combined P < 5 × 10−8.
Journal ArticleDOI
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Mary F. Feitosa,Aldi T. Kraja,Daniel I. Chasman,Yun J. Sung,Thomas W. Winkler,Ioanna Ntalla,Xiuqing Guo,Nora Franceschini,Ching-Yu Cheng,Ching-Yu Cheng,Xueling Sim,Dina Vojinovic,Jonathan Marten,Solomon K. Musani,Changwei Li,Amy R. Bentley,Michael R. Brown,Karen Schwander,Melissa A. Richard,Raymond Noordam,Hugues Aschard,Hugues Aschard,Traci M. Bartz,Lawrence F. Bielak,Rajkumar Dorajoo,Virginia Fisher,Fernando Pires Hartwig,Fernando Pires Hartwig,Andrea R. V. R. Horimoto,Kurt Lohman,Alisa K. Manning,Tuomo Rankinen,Albert V. Smith,Salman M. Tajuddin,Mary K. Wojczynski,Maris Alver,Mathilde Boissel,Qiuyin Cai,Archie Campbell,Jin-Fang Chai,Xu Chen,Jasmin Divers,Chuan Gao,Anuj Goel,Yanick Hagemeijer,Sarah E. Harris,Meian He,Fang-Chi Hsu,Anne U. Jackson,Mika Kähönen,Anuradhani Kasturiratne,Pirjo Komulainen,Brigitte Kühnel,Federica Laguzzi,Jian'an Luan,Nana Matoba,Ilja M. Nolte,Sandosh Padmanabhan,Muhammad Riaz,Muhammad Riaz,Rico Rueedi,Antonietta Robino,M. Abdullah Said,Robert A. Scott,Tamar Sofer,Alena Stančáková,Fumihiko Takeuchi,Bamidele O. Tayo,Peter J. van der Most,Tibor V. Varga,Veronique Vitart,Yajuan Wang,Erin B. Ware,Helen R. Warren,Stefan Weiss,Wanqing Wen,Lisa R. Yanek,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Saima Afaq,Najaf Amin,Marzyeh Amini,Dan E. Arking,Tin Aung,Tin Aung,Eric Boerwinkle,Eric Boerwinkle,Ingrid B. Borecki,Ulrich Broeckel,Morris J. Brown,Marco Brumat,Gregory L. Burke,Mickaël Canouil,Aravinda Chakravarti,Sabanayagam Charumathi,Sabanayagam Charumathi,Yii-Der Ida Chen,John M. C. Connell,Adolfo Correa,Lisa de las Fuentes,Renée de Mutsert,H. Janaka de Silva,Xuan Deng,Jingzhong Ding,Qing Duan,Charles B. Eaton,Georg Ehret,Ruben N. Eppinga,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Stephan B. Felix,Nita G. Forouhi,Terrence Forrester,Oscar H. Franco,Yechiel Friedlander,Ilaria Gandin,He Gao,Mohsen Ghanbari,Mohsen Ghanbari,Bruna Gigante,C. Charles Gu,Dongfeng Gu,Saskia P. Hagenaars,Göran Hallmans,Tamara B. Harris,Jiang He,Sami Heikkinen,Chew-Kiat Heng,Makoto Hirata,Barbara V. Howard,M. Arfan Ikram,Ulrich John,Tomohiro Katsuya,Chiea Chuen Khor,Chiea Chuen Khor,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Woon-Puay Koh,José Eduardo Krieger,Stephen B. Kritchevsky,Michiaki Kubo,Johanna Kuusisto,Timo A. Lakka,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Benjamin Lehne,Cora E. Lewis,Yize Li,Shiow Lin,Jianjun Liu,Jianjun Liu,Jingmin Liu,Marie Loh,Marie Loh,Tin Louie,Reedik Mägi,Colin A. McKenzie,Thomas Meitinger,Andres Metspalu,Yuri Milaneschi,Lili Milani,Karen L. Mohlke,Yukihide Momozawa,Mike A. Nalls,Christopher P. Nelson,Christopher P. Nelson,Nona Sotoodehnia,Jill M. Norris,Jeffrey R. O'Connell,Nicholette D. Palmer,Thomas T. Perls,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Neil Poulter,Leslie J. Raffel,Olli T. Raitakari,Kathryn Roll,Lynda M. Rose,Frits R. Rosendaal,Jerome I. Rotter,Carsten Oliver Schmidt,Pamela J. Schreiner,Nicole Schupf,William R. Scott,Peter S. Sever,Yuan Shi,Stephen Sidney,Mario Sims,Colleen M. Sitlani,Jennifer A. Smith,Harold Snieder,John M. Starr,Konstantin Strauch,Heather M. Stringham,Nicholas Y.Q. Tan,Hua Tang,Kent D. Taylor,Yik Ying Teo,Yik Ying Teo,Yih Chung Tham,Stephen Turner,André G. Uitterlinden,Peter Vollenweider,Melanie Waldenberger,Lihua Wang,Ya Xing Wang,Wen Bin Wei,Christine Williams,Jie Yao,Caizheng Yu,Jian-Min Yuan,Wei Zhao,Alan B. Zonderman,Diane M. Becker,Michael Boehnke,Donald W. Bowden,John C. Chambers,John C. Chambers,John C. Chambers,Ian J. Deary,Tõnu Esko,Tõnu Esko,Martin Farrall,Paul W. Franks,Paul W. Franks,Barry I. Freedman,Philippe Froguel,Philippe Froguel,Paolo Gasparini,Christian Gieger,Jost B. Jonas,Jost B. Jonas,Yoichiro Kamatani,Norihiro Kato,Jaspal S. Kooner,Jaspal S. Kooner,Zoltán Kutalik,Markku Laakso,Cathy C. Laurie,Karin Leander,Terho Lehtimäki,Patrik K. E. Magnusson,Albertine J. Oldehinkel,Brenda W.J.H. Penninx,Ozren Polasek,Ozren Polasek,David J. Porteous,Rainer Rauramaa,Nilesh J. Samani,Nilesh J. Samani,James Scott,Xiao-Ou Shu,Pim van der Harst,Lynne E. Wagenknecht,Nicholas J. Wareham,Hugh Watkins,David R. Weir,Ananda R. Wickremasinghe,Tangchun Wu,Wei Zheng,Claude Bouchard,Kaare Christensen,Michele K. Evans,Vilmundur Gudnason,Bernardo L. Horta,Sharon L.R. Kardia,Yongmei Liu,Alexandre C. Pereira,Bruce M. Psaty,Bruce M. Psaty,Paul M. Ridker,Rob M. van Dam,W. James Gauderman,Xiaofeng Zhu,Dennis O. Mook-Kanamori,Myriam Fornage,Charles N. Rotimi,L. Adrienne Cupples,L. Adrienne Cupples,Tanika N. Kelly,Ervin R. Fox,Caroline Hayward,Cornelia M. van Duijn,E. Shyong Tai,Tien Yin Wong,Tien Yin Wong,Charles Kooperberg,Walter Palmas,Kenneth Rice,Alanna C. Morrison,Paul Elliott,Mark J. Caulfield,Patricia B. Munroe,Dabeeru C. Rao,Michael A. Province,Daniel Levy +299 more
TL;DR: In insights into the role of alcohol consumption in the genetic architecture of hypertension, a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions is conducted.
Journal ArticleDOI
Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data
Donald E. G. Griesdale,Russell J. de Souza,Rob M. van Dam,Daren K. Heyland,Deborah J. Cook,Atul Malhotra,Rupinder Dhaliwal,William R. Henderson,Dean R. Chittock,Simon Finfer,Daniel Talmor +10 more
TL;DR: Intensive insulin therapy significantly increased the risk of hypoglycemia and conferred no overall mortality benefit among critically ill patients, but this therapy may be beneficial to patients admitted to a surgical ICU.
Journal ArticleDOI
Systematic Review of Type 1 and Type 2 Diabetes Mellitus and Risk of Fracture
Mohsen Janghorbani,Mohsen Janghorbani,Rob M. van Dam,Walter C. Willett,Walter C. Willett,Frank B. Hu,Frank B. Hu +6 more
TL;DR: An association between both type 1 and type 2 diabetes and increased risk of hip fracture in men and women and between studies conducted in the United States and Europe is supported.