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Robert A. Redd

Researcher at Harvard University

Publications -  54
Citations -  984

Robert A. Redd is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & Diffuse large B-cell lymphoma. The author has an hindex of 13, co-authored 54 publications receiving 454 citations.

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Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

TL;DR: In this paper, the authors evaluated the long-term effects of personal neoantigen vaccines and found that they can induce durable and specific memory T cell clones that have cytotoxic gene signatures and can diversify to include non-vaccine specificities.
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A peripheral immune signature of responsiveness to PD-1 blockade in patients with classical Hodgkin lymphoma

TL;DR: In a phase II clinical trial of patients with classical Hodgkin lymphoma, peripheral CD4+ T cell receptor diversity and the abundance of mature natural killer cells and CD3−CD68+CD4+GrB+ innate cells were associated with favorable responses to anti-PD-1 monotherapy.
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Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.

TL;DR: A comprehensive analysis of recurrent genetic alterations - somatic mutations, somatic copy number alterations (SCNAs) and structural variants - in a cohort of 37 newly diagnosed primary mediastinal large B-cell lymphomas finds several previously uncharacterized molecular features that may increase sensitivity to PD-1 blockade.