scispace - formally typeset
Author

Robert A. Weinberg

Bio: Robert A. Weinberg is a academic researcher at Massachusetts Institute of Technology who has co-authored 477 publication(s) receiving 240903 citation(s). The author has an hindex of 190. Previous affiliations of Robert A. Weinberg include Worcester Foundation for Biomedical Research. The author has done significant research in the topic(s): Gene & Cancer.

...read more

Topics: Gene, Cancer, Cancer stem cell ...read more
Papers
  More

Open accessJournal ArticleDOI: 10.1016/J.CELL.2011.02.013
Douglas Hanahan1, Robert A. Weinberg2Institutions (2)
04 Mar 2011-Cell
Abstract: The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list-reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the "tumor microenvironment." Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.

...read more

42,275 Citations


Open accessJournal ArticleDOI: 10.1016/S0092-8674(00)81683-9
Douglas Hanahan1, Robert A. Weinberg2Institutions (2)
07 Jan 2000-Cell
Abstract: We wish to thank Terry Schoop of Biomed Arts Associates, San Francisco, for preparation of the figures, Cori Bargmann and Zena Werb for insightful comments on the manuscript, and Normita Santore for editorial assistance. In addition, we are indebted to Joe Harford and Richard Klausner, who allowed us to adapt and expand their depiction of the cell signaling network, and we appreciate suggestions on signaling pathways from Randy Watnick, Brian Elenbas, Bill Lundberg, Dave Morgan, and Henry Bourne. R. A. W. is a Ludwig Foundation and American Cancer Society Professor of Biology. His work has been supported by the Department of the Army and the National Institutes of Health. D. H. acknowledges the support and encouragement of the National Cancer Institute. Editorial policy has rendered the citations illustrative but not comprehensive.

...read more

26,950 Citations


Open accessJournal ArticleDOI: 10.1172/JCI39104
Raghu Kalluri1, Robert A. Weinberg2Institutions (2)
Abstract: The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias. The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.

...read more

7,540 Citations


Open accessJournal ArticleDOI: 10.1016/J.CELL.2008.03.027
Sendurai A. Mani1, Wenjun Guo1, Mai Jing Liao1, Elinor Ng Eaton1  +11 moreInstitutions (4)
16 May 2008-Cell
Abstract: The epithelial-mesenchymal transition (EMT) is a key developmental program that is often activated during cancer invasion and metastasis. We here report that the induction of an EMT in immortalized human mammary epithelial cells (HMLEs) results in the acquisition of mesenchymal traits and in the expression of stem-cell markers. Furthermore, we show that those cells have an increased ability to form mammospheres, a property associated with mammary epithelial stem cells. Independent of this, stem cell-like cells isolated from HMLE cultures form mammospheres and express markers similar to those of HMLEs that have undergone an EMT. Moreover, stem-like cells isolated either from mouse or human mammary glands or mammary carcinomas express EMT markers. Finally, transformed human mammary epithelial cells that have undergone an EMT form mammospheres, soft agar colonies, and tumors more efficiently. These findings illustrate a direct link between the EMT and the gain of epithelial stem cell properties.

...read more

7,441 Citations


Open accessJournal ArticleDOI: 10.1016/0092-8674(95)90385-2
Robert A. Weinberg1Institutions (1)
05 May 1995-Cell
Abstract: pRB, the product of the retinoblastoma tumor suppressor gene, operates in the midst of the cell cycle clock apparatus. Its main role is to act as a signal transducer connecting the cell cycle clock with the transcriptional machinery. In this role, pRB allows the clock to control the expression of banks of genes that mediate advance of the cell through a critical phase of its growth cycle. Loss of pRB function deprives the clock and thus the cell of an important mechanism for braking cell proliferation through modulation of gene expression.

...read more

Topics: Retinoblastoma protein (70%), Cell Cycle Protein (65%), Restriction point (63%) ...read more

4,790 Citations


Cited by
  More

Open accessJournal ArticleDOI: 10.1016/J.CELL.2011.02.013
Douglas Hanahan1, Robert A. Weinberg2Institutions (2)
04 Mar 2011-Cell
Abstract: The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list-reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the "tumor microenvironment." Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.

...read more

42,275 Citations


Open accessJournal ArticleDOI: 10.1016/S0092-8674(00)81683-9
Douglas Hanahan1, Robert A. Weinberg2Institutions (2)
07 Jan 2000-Cell
Abstract: We wish to thank Terry Schoop of Biomed Arts Associates, San Francisco, for preparation of the figures, Cori Bargmann and Zena Werb for insightful comments on the manuscript, and Normita Santore for editorial assistance. In addition, we are indebted to Joe Harford and Richard Klausner, who allowed us to adapt and expand their depiction of the cell signaling network, and we appreciate suggestions on signaling pathways from Randy Watnick, Brian Elenbas, Bill Lundberg, Dave Morgan, and Henry Bourne. R. A. W. is a Ludwig Foundation and American Cancer Society Professor of Biology. His work has been supported by the Department of the Army and the National Institutes of Health. D. H. acknowledges the support and encouragement of the National Cancer Institute. Editorial policy has rendered the citations illustrative but not comprehensive.

...read more

26,950 Citations


Open access
28 Jul 2005-
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

...read more

18,940 Citations


Journal ArticleDOI: 10.1126/SCIENCE.3798106
Dennis J. Slamon1, Gary M. Clark2, Steven G. Wong1, Wendy J. Levin1  +2 moreInstitutions (3)
09 Jan 1987-Science
Abstract: The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be amplified in human breast cancer cell lines. In the current study, alterations of the gene in 189 primary human breast cancers were investigated. HER-2/neu was found to be amplified from 2- to greater than 20-fold in 30% of the tumors. Correlation of gene amplification with several disease parameters was evaluated. Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer. It retained its significance even when adjustments were made for other known prognostic factors. Moreover, HER-2/neu amplification had greater prognostic value than most currently used prognostic factors, including hormonal-receptor status, in lymph node-positive disease. These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of human breast cancer.

...read more

Topics: HER2/neu (74%), HER2/Neu Status (66%), Lapatinib (60%) ...read more

11,086 Citations


Open accessJournal ArticleDOI: 10.1038/NATURE01322
Lisa M. Coussens1, Zena Werb1Institutions (1)
19 Dec 2002-Nature
Abstract: Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development.

...read more

Topics: Cytokine (54%), Inflammation (52%), Innate immune system (52%)

11,085 Citations


Performance
Metrics

Author's H-index: 190

No. of papers from the Author in previous years
YearPapers
20217
20208
20196
20188
201713
20168

Top Attributes

Show by:

Author's top 5 most impactful journals

Cell

50 papers, 114.1K citations

Nature

44 papers, 30.1K citations

Cancer Research

19 papers, 4.1K citations

Science

16 papers, 9K citations

Network Information
Related Authors (5)
Ferenc Reinhardt

63 papers, 14.8K citations

92% related
Roderick T. Bronson

679 papers, 107.7K citations

89% related
Christine L. Chaffer

33 papers, 11.3K citations

89% related
Tyler Jacks

463 papers, 115.1K citations

88% related
Prathapan Thiru

32 papers, 3.8K citations

87% related