Robert Aigner

TL;DR: It is demonstrated that quantification of DCX‐expressing cells allows for an accurate measurement of modulations in the rate of adult neurogenesis, and DCX is a valuable alternative to techniques currently used to measure the levels of Neurogenesis.

TL;DR: Rather than replacing old neurons, this data suggests that adult olfactory bulb neurogenesis utilizes the overproduction and turnover of young neurons, which is reminiscent of the cellular dynamics observed during brain development.

TL;DR: Investigation of adult neurogenesis and the neurite development of new neurons in the DG and SVZ/olfactory bulb system in bacterial artificial chromosome (BAC) human Lrrk2 G2019S transgenic mice reports that mutant human LRRk2 is highly expressed in the hippocampus in the hippocampal dentate gyrus and the SVZ of adult LrrK2 G 2019S mice, and physical activity partially reverses the decrease in neuroblasts.

TL;DR: It is suggested that TGF-&bgr;1 is an important signaling molecule involved in the control of neural stem and progenitor cell proliferation in the CNS, which might have potential implications for neurogenesis in a variety of TGF -&b gr;1-associated CNS diseases and pathologic conditions.

TL;DR: Evidence is supported that neurotransmitters play a crucial role in determining survival and differentiation of newly generated neurons in the olfactory bulb layers and that loss of dopaminergic input to the SVZ led to a distinct cell fate decision towards stimulation of dopamine neurogenesis in the Olfactory bulbs.