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Robert Blelloch
Researcher at University of California, San Francisco
Publications - 108
Citations - 13873
Robert Blelloch is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 47, co-authored 100 publications receiving 12552 citations. Previous affiliations of Robert Blelloch include Brigham and Women's Hospital & University of California.
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Journal ArticleDOI
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
TL;DR: It is indicated that miRNAs function in the silencing of ES cell self-renewal that normally occurs with the induction of differentiation, and Dicer has miRNA-independent roles in ES cell function.
Journal ArticleDOI
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
TL;DR: The results extend the known diversity of mammalian small RNA-generating pathways and show that mammalian siRNAs exist in cell types other than oocytes.
Journal ArticleDOI
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
H. Rosaria Chiang,Lori W. Schoenfeld,J. Graham Ruby,Vincent C. Auyeung,Noah Spies,Daehyun Baek,Wendy K. Johnston,Carsten Russ,Shujun Luo,Joshua E. Babiarz,Robert Blelloch,Gary P. Schroth,Chad Nusbaum,David P. Bartel +13 more
TL;DR: In this paper, the authors sequenced 60 million small RNAs from mouse brain, ovary, testes, embryonic stem cells, three embryonic stages, and whole newborns.
Journal ArticleDOI
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
Mauro Poggio,Tianyi Hu,Chien Chun Pai,Brandon Chu,Cassandra D. Belair,Anthony Chang,Elizabeth Montabana,Ursula E. Lang,Qi Fu,Lawrence Fong,Robert Blelloch +10 more
TL;DR: The findings show that exosomal PD-L1 represents an unexplored therapeutic target, which could overcome resistance to current antibody approaches, and is described as a potential new therapeutic target for cancer patients.
PatentDOI
Embryonic stem cell specific microRNAs promote induced pluripotency
TL;DR: In this paper, the introduction of physiologically relevant miRNAs can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (iPS cells).