R
Robert Fredriksson
Researcher at Uppsala University
Publications - 197
Citations - 14125
Robert Fredriksson is an academic researcher from Uppsala University. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 58, co-authored 188 publications receiving 12705 citations. Previous affiliations of Robert Fredriksson include University of St. Gallen & Swedish University of Agricultural Sciences.
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The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families : Phylogenetic Analysis, Paralogon Groups, and Fingerprints
TL;DR: This study represents the first overall map of the GPCR sequences in a single mammalian genome and shows several common structural features indicating that the human GPCRs in the GRAFS families share a common ancestor.
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The repertoire of G-protein-coupled receptors in fully sequenced genomes.
TL;DR: The results show that the main families in the human genome, Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin, arose before the split of nematodes from the chordate lineage.
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Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin
TL;DR: It is estimated that 27% of the total human proteome are alpha-helical transmembrane proteins and this work provides an extended classification together with in-depth investigations of the membrane proteome's functional, structural, and evolutionary features.
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Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Thóra K. Bjarnadóttir,David E. Gloriam,Sofia H. Hellstrand,Helena Kristiansson,Robert Fredriksson,Helgi B. Schiöth +5 more
TL;DR: This is the most comprehensive study of the gene repertoire that codes for human and mouse GPCRs with a phylogenetic road map and searches for expressed sequence tags (ESTs) identified more than 17,000 ESTs matching GPCRS in mouse and human, providing information about their expression patterns.
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The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
Robert Fredriksson,Maria Hägglund,Pawel K. Olszewski,Olga Stephansson,Josefin A. Jacobsson,Agnieszka M. Olszewska,Allen S. Levine,Jonas Lindblom,Helgi B. Schiöth +8 more
TL;DR: The FTO gene is predominantly expressed in neurons, whereas it was virtually not found in astrocytes or glia cells, consistent with the hypothesis that FTO could participate in the central control of energy homeostasis.