R
Robert Freeman
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 81
Citations - 5332
Robert Freeman is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Psychological intervention. The author has an hindex of 26, co-authored 68 publications receiving 4073 citations. Previous affiliations of Robert Freeman include Harvard University & Mount Sinai Hospital.
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Journal ArticleDOI
A Tissue-Mapped Axolotl De Novo Transcriptome Enables Identification of Limb Regeneration Factors
Donald M. Bryant,Kimberly Johnson,Tia DiTommaso,Timothy L. Tickle,M. B. Couger,Duygu Payzin-Dogru,Tae J. Lee,Nicholas D. Leigh,Tzu-Hsing Kuo,Francis G. Davis,Joel Bateman,Sevara Bryant,Anna R. Guzikowski,Stephanie L. Tsai,Steven Coyne,William W. Ye,Robert Freeman,Leonid Peshkin,Clifford J. Tabin,Aviv Regev,Brian J. Haas,Jessica L. Whited +21 more
TL;DR: A de novo transcriptome is assembled and annotated using RNA-sequencing profiles for a broad spectrum of tissues that is estimated to have near-complete sequence information for 88% of axolotl genes and finds evidence that cirbp plays a cytoprotective role during limb regeneration whereas manipulation of kazald1 expression disrupts regeneration.
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Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida
Sarah J. Bourlat,Thorhildur Juliusdottir,Christopher J. Lowe,Robert Freeman,Jochanan Aronowicz,Mark Kirschner,Eric S. Lander,Eric S. Lander,Michael C. Thorndyke,Hiroaki Nakano,Andrea B. Kohn,Andreas Heyland,Leonid L. Moroz,Richard R. Copley,Maximilian J. Telford +14 more
TL;DR: To study the relationships among all deuterostome groups, an alignment of more than 35,000 homologous amino acids is assembled, including new data from a hemichordate, starfish and Xenoturbella and it is concluded that chordates are monophyletic.
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AKI in hospitalized patients with COVID-19
Lili Chan,Kumardeep Chaudhary,Aparna Saha,Kinsuk Chauhan,Akhil Vaid,Shan Zhao,Ishan Paranjpe,Sulaiman Somani,Felix Richter,Riccardo Miotto,Anuradha Lala,Arash Kia,Prem Timsina,Li Li,Robert Freeman,Rong Chen,Jagat Narula,Allan C. Just,Carol R. Horowitz,Zahi A. Fayad,Carlos Cordon-Cardo,Eric E. Schadt,Matthew A. Levin,David Reich,Valentin Fuster,Barbara Murphy,John Cijiang He,Alexander W. Charney,Erwin P. Bottinger,Benjamin S. Glicksberg,Steven G. Coca,Girish N. Nadkarni +31 more
TL;DR: This retrospective, observational study involved a review of data from electronic health records of patients aged ≥18 years with laboratory-confirmed COVID-19 admitted to the Mount Sinai Health System from February 27 to May 30, 2020 to describe the frequency of AKI and dialysis requirement, AKI recovery, and adjusted odds ratios with mortality.
Journal ArticleDOI
Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
TL;DR: Several mechanisms by which SH-PTP2 may participate in mammalian signal transduction are suggested, including corkscrew, which acts in concert with D-raf to positively transduce the signal generated by the receptor tyrosine kinase torso.
Journal ArticleDOI
The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus development
TL;DR: The results indicate that SH-PTP2 is required for early vertebrate development, acting as a positive component in FGF signaling downstream of the FGF receptor and upstream of MAP kinase.