Robert H. Ring

TL;DR: Se sequencing of 5,205 samples from families with ASD, accompanied by clinical information, creating a database accessible on a cloud platform and through a controlled-access internet portal that identified 18 new candidate ASD-risk genes and found that participants bearing mutations in susceptibility genes had significantly lower adaptive ability.

TL;DR: By examining de novo and rare inherited single-nucleotide and structural variations in genes previously reported to be associated with ASD or other neurodevelopmental disorders, it is found that some of the affected siblings carried different ASD-relevant mutations.

TL;DR: Results suggest that WGS and thorough bioinformatic analyses for de novo and rare inherited mutations will improve the detection of genetic variants likely to be associated with ASD or its accompanying clinical symptoms.

TL;DR: In this paper, the authors performed whole-genome sequencing (WGS) of 200 ASD parent-child trios and characterized germline and somatic DNMs and found that the majority of germline DNMs (75.6%) originated from the father and these increased significantly with paternal age only (p=4.2×10-10).

TL;DR: These data provide an important confirmation and expansion of the anxiolytic-like effects of NPS and implicate the NPS system as a novel target for anxIOlytic drug discovery.