R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
TL;DR: Results indicate that post-translational modification by palmitate of beta 2AR may play a crucial role in the normal coupling of the receptor to the adenylyl cyclase signal transduction system.
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The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.
Randy A. Hall,Richard T. Premont,Chung-Wai Chow,Jeremy T. Blitzer,Julie A. Pitcher,Audrey Claing,Robert H. Stoffel,Robert H. Stoffel,Larry S. Barak,Shirish Shenolikar,Edward J. Weinman,Edward J. Weinman,Edward J. Weinman,Sergio Grinstein,Robert J. Lefkowitz +14 more
TL;DR: It is reported here a direct agonist-promoted association of the β2-adrenergic receptor with the Na+/H+ exchanger regulatory factor (NHERF), a protein that regulates the activity of the Na-H- exchanger type 3 (NHE3).
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β-Arrestin-biased ligands at seven-transmembrane receptors
TL;DR: The current state of β-arrestin-biased ligand research and the prospects for β-Arrestin bias as a therapeutic target are discussed, which might have profound influences on the way scientists approach 7TMR-targeted drug discovery.
Journal Article
Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.
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Cloning of the cDNA for the human beta 1-adrenergic receptor.
Thomas Frielle,Sheila Collins,Kiefer W. Daniel,Marc G. Caron,Robert J. Lefkowitz,Brian K. Kobilka +5 more
TL;DR: RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of tissue distribution consistent with beta 1AR binding, which suggests that the avian gene encoding beta AR and the human gene encodingbeta 1AR evolved from a common ancestral gene.