R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.
TL;DR: Diminished coupling of beta adrenergic receptors with other regulatory components of the adenylate cyclase system represents a mechanism by which altered thyroid states modulatebeta adrenergic receptor function andBeta adrenergic responsiveness of tissues.
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Targeting G protein-coupled receptor kinases to their receptor substrates
TL;DR: It is within these two domains that the GRKs are most variable at the amino acid level, and the GRKS exhibit an absolute requirement for phospholipids not only for association with the membrane but also for activity.
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Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes.
L J Pike,Robert J. Lefkowitz +1 more
Journal Article
Adrenergic receptors: recent insights into their mechanism of activation and desensitization.
Robert J. Lefkowitz,Susanna Cotecchia,Michael A. Kjelsberg,Pitcher J,Walter J. Koch,J. Inglese,Marc G. Caron +6 more
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Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6.
TL;DR: Palmitoylation of GRK6 appears to play a dual role in increasing the activity ofGRK6: it increases the hydrophobicity and membrane association of the GRK 6 protein, which helps bring the GR k6 to its membrane-bound substrates, and it increasesThe kinase catalytic activity of GRk6.