R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
Kenji Ishii,Ji Chen,Maki Ishii,W. J. Koch,Neil J. Freedman,Robert J. Lefkowitz,Shaun R. Coughlin +6 more
TL;DR: It is reported that the thrombin receptor is rapidly phosphorylated upon activation, consistent with the action of a G- protein-coupled receptor kinase, and the G-protein coupled receptor kinases BARK2 (beta-adrenergic receptors kinase 2) blocked signaling by throm bin receptors coexpressed in Xenopus oocytes.
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Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.
TL;DR: Regulation of the concentration of functionally active beta-adrenergic receptors in membranes may be one of the mechanisms by which chronic exposure to catecholamines desensitizes tissues to beta- adrenergic stimulation.
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GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
Bryan E. Snow,Randy A. Hall,Andrejs M. Krumins,Denis Bouchard,Stephen Chung,Joan Mangion,Alfred G. Gilman,Robert J. Lefkowitz,David P. Siderovski +8 more
TL;DR: The presence of an alternatively spliced PDZ domain within RGS12 suggests a mechanism by which RGS proteins may target specific G-protein-coupled receptor systems for desensitization.
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Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery
John P. Maurice,Jonathan A. Hata,Ashish S. Shah,David C. White,Patricia McDonald,Paul C. Dolber,Katrina H. Wilson,Robert J. Lefkowitz,Donald D. Glower,Walter J. Koch +9 more
TL;DR: It is demonstrated that global myocardial in vivo gene delivery is possible and that genetic manipulation of beta-AR density can result in enhanced cardiac performance, and replacement of lost receptors seen in HF may represent novel inotropic therapy.
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Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution
TL;DR: In this paper, it was shown that the phosphorylation state of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase, subcellular translocation, and recycling to the cell surface during the process of agonist-induced homologous desensitization.