R
Robert J. Lefkowitz
Researcher at Howard Hughes Medical Institute
Publications - 867
Citations - 153371
Robert J. Lefkowitz is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 214, co-authored 860 publications receiving 147995 citations. Previous affiliations of Robert J. Lefkowitz include University of Nice Sophia Antipolis & University of Stuttgart.
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Journal ArticleDOI
Overview of the Alliance for Cellular Signaling.
Alfred G. Gilman,Melvin I. Simon,Henry R. Bourne,Bruce A. Harris,Rochelle Long,Elliott M. Ross,James T. Stull,Ronald Taussig,Adam P. Arkin,Melanie H. Cobb,Jason G. Cyster,Peter N. Devreotes,James E. Ferrell,David A. Fruman,Michael R. Gold,Arthur Weiss,Michael J. Berridge,Lewis C. Cantley,William A. Catterall,Shaun R. Coughlin,Eric N. Olson,Temple F. Smith,Joan S. Brugge,David Botstein,Jack E. Dixon,Tony Hunter,Robert J. Lefkowitz,Anthony J. Pawson,Paul W. Sternberg,Harold E. Varmus,Shankar Subramaniam,Robert S. Sinkovits,Joshua Li,Dennis Mock,Yuhong Ning,Brian Saunders,Paul C. Sternweis,Donald W. Hilgemann,Richard H. Scheuermann,Dianne L. DeCamp,Robert C. Hsueh,Keng Mean Lin,Yan Ni,William E. Seaman,Paul C. Simpson,Timothy D. O'Connell,Tamara I. A. Roach,Sangdun Choi,Pamela Eversole-Cire,Iain D. C. Fraser,Marc C. Mumby,Yingming Zhao,Deirdre L. Brekken,Hongjun Shu,Tobias Meyer,Grischa Chandy,Won Do Heo,Jen Liou,Nancy A. O'Rourke,Mary Verghese,Susanne M. Mumby,Heping Han,H. Alex Brown,Jeffrey Forrester,Pavlina T. Ivanova,Stephen B. Milne,Patrick J. Casey,T. Kendall Harden,John Doyle,Martha L. Gray,Stephen W. Michnick,Martin A. Schmidt,Mehmet Toner,Roger Y. Tsien,Madhusudan Natarajan,Rama Ranganathan,Gilberto R. Sambrano +76 more
TL;DR: The Alliance for Cellular Signaling will study intensively in two cells — B lymphocytes (the cells of the immune system) and cardiac myocytes — to facilitate quantitative modelling.
Journal ArticleDOI
The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2.
Kelly N. Nobles,Ziqiang Guan,Kunhong Xiao,Terrence G. Oas,Robert J. Lefkowitz,Robert J. Lefkowitz +5 more
TL;DR: This study determines conformational changes in beta-arrestin1 using limited tryptic proteolysis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis in the presence of a phosphopeptide derived from the C terminus of the V(2) vasopressin receptor or the corresponding unphosphorylated peptide (V( 2)Rnp).
Journal ArticleDOI
Agonist-induced increase in apparent β-adrenergic receptor size
TL;DR: The low concentrations of agonist that are capable of altering apparent receptor size and the sensitivity of this effect to guanyl nucleotides suggest that these phenomena may be intimately involved in eliciting the physiological effects of β-adrenergic catecholamines at the molecular level.
Journal ArticleDOI
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein
TL;DR: Results suggest that G beta gamma-stimulated Shc phosphorylation represents an early step in the pathway leading to p21ras activation, similar to the mechanism utilized by growth factor tyrosine kinase receptors.
Journal ArticleDOI
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.
Jay P. McLaughlin,Lisa C. Myers,Paul E. Zarek,Marc G. Caron,Robert J. Lefkowitz,Traci A. Czyzyk,John E. Pintar,Charles Chavkin +7 more
TL;DR: The coincident reversal of analgesic tolerance and slow return to a basal phosphorylation state matched the regeneration rate of functional kappa receptors following irreversible antagonism and suggested that receptor replacement rather than dephosphorylation was required to restore sensitivity.