R
Robert J. Linhardt
Researcher at Rensselaer Polytechnic Institute
Publications - 1256
Citations - 60996
Robert J. Linhardt is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Heparin & Heparan sulfate. The author has an hindex of 58, co-authored 1190 publications receiving 53368 citations. Previous affiliations of Robert J. Linhardt include Complutense University of Madrid & University of Georgia.
Papers
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Journal ArticleDOI
Heparin-protein interactions
Ishan Capila,Robert J. Linhardt +1 more
TL;DR: This review focuses on aspects of heparin structure and conformation, which are important for its interactions with proteins, and describes the interaction ofheparin and heparan sulfate with selected families of heParin-binding proteins.
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Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization
Joseph Schlessinger,Alexander N. Plotnikov,Omar A. Ibrahimi,Anna V. Eliseenkova,Brian K. Yeh,Avner Yayon,Robert J. Linhardt,Moosa Mohammadi +7 more
TL;DR: This model provides a structural basis for FGFR activation by small molecule Heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling.
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Flexible energy storage devices based on nanocomposite paper
Victor L. Pushparaj,Manikoth M. Shaijumon,Ashok Kumar,Saravanababu Murugesan,Lijie Ci,Robert Vajtai,Robert J. Linhardt,Omkaram Nalamasu,Pulickel M. Ajayan +8 more
TL;DR: This work shows that basic components, the electrode, separator, and electrolyte, can all be integrated into single contiguous nanocomposite units that can serve as building blocks for a variety of thin mechanically flexible energy storage devices.
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Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
Yaping Chen,Terry Maguire,Ronald E. Hileman,Jonathan R. Fromm,Jeffrey D. Esko,Robert J. Linhardt,Rory M. Marks +6 more
TL;DR: Heparin, highly sulfated heparan sulfate, and the polysulfonate pharmaceutical Suramin effectively prevented dengue virus infection of target cells, indicating that the envelope protein-target cell receptor interaction is a critical determinant of infectivity.
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Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis
TL;DR: The ionic liquid, 1‐ethyl‐3‐methylimidazolium acetate ([Emim][CH3COO]), was used as a pretreatment solvent to extract lignin from wood flour, resulting in a highly concentrated solution of chemically unmodified lign in, which may serve as a valuable source of a polyaromatic material as a value‐added product.