Diagnosis and definition of treatment-resistant depression

Quality of life is an important health outcome in its own right, representing the ultimate goal of all health interventions. This paper reviews the published, English-language literature on self-perceived quality of life among adults with diabetes. Quality of life is measured as physical and social functioning, and perceived physical and mental well-being. People with diabetes have a worse quality of life than people with no chronic illness, but a better quality of life than people with most other serious chronic diseases. Duration and type of diabetes are not consistently associated with quality of life. Intensive treatment does not impair quality of life, and having better glycemic control is associated with better quality of life. Complications of diabetes are the most important disease-specific determinant of quality of life. Numerous demographic and psychosocial factors influence quality of life and should be controlled when comparing subgroups. Studies of clinical and educational interventions suggest that improving patients' health status and perceived ability to control their disease results in improved quality of life. Methodologically, it is important to use multidimensional assessments of quality of life, and to include both generic and disease-specific measures. Quality of life measures should be used to guide and evaluate treatment interventions.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/%28SICI%291520-7560%28199905/06%2915%3A3%3C205%3A%3AAID-DMRR29%3E3.0.CO%3B2-O

Quality of life and diabetes

The role of health care providers and significant others in evaluating the quality of life of patients with chronic disease: A review

We examined the relationship between perceived emotional intelligence (PEI), measured by the Trait Meta-Mood Scale (TMMS), and psychophysiological measures of adaptive coping. The TMMS assesses perceived ability to (a) attend to moods (Attention), (b) discriminate clearly among moods (Clarity), and (c) regulate moods (Repair). Study 1 showed significant positive associations between PEI and psychological and interpersonal functioning. In Study 2, skill at mood Repair was associated with less passive coping and perceptions of repeated laboratory stressors as less threatening; Clarity was related to greater increases in negative mood, but lower cortisol release during repeated stress. In Study 3, Repair was associated with active coping and lower levels of rumination; Attention was associated with lowered cortisol and blood pressure responses to acute laboratory challenges. These findings suggest that psychophysiological responses to stress may be one potential mechanism underlying the relationship between ...

Perceived emotional intelligence, stress reactivity, and symptom reports: Further explorations using the trait meta-mood scale.

Volumetric MRI scans from 26 women with repeated episodes of childhood sexual abuse and 17 healthy female comparison subjects (ages 18-22 years) were analyzed for sensitive period effects on hippocampal and amygdala volume, frontal cortex gray matter volume and corpus callosum area. Hippocampal volume was reduced in association with childhood sexual abuse at ages 3-5 years and ages 11-13 years. Corpus callosum was reduced with childhood sexual abuse at ages 9-10 years, and frontal cortex was attenuated in subjects with childhood sexual abuse at ages 14-16 years. Brain regions have unique windows of vulnerability to the effects of traumatic stress.

/pdf/preliminary-evidence-for-sensitive-periods-in-the-effect-of-37ggznkp61.pdf

Preliminary Evidence for Sensitive Periods in the Effect of Childhood Sexual Abuse on Regional Brain Development

The Symptom Questionnaire (SQ) is a yes/no questionnaire with brief and simple items. It contains state scales of depression, anxiety, anger-hostility, and somatic symptoms. It was developed from earlier versions to make the scales more sensitive for clinical research. The scales have been extensively validated. The psychometric properties of the SQ are somewhat different from those of similar scales. In double-blind, crossover studies, they tended to be more sensitive than other scales in discriminating between the effects of a psychotropic drug and placebo and were found to be highly sensitive in discriminating between distress levels of groups. In studies with small or moderately sized samples in which the sensitivity of scales is important or in populations that include subjects with poor verbal skills, the SQ seems to have advantages. The SQ is suitable for the measurement of distress and hostility in research and as a checklist in clinical work.

Robert Kellner

Papers

A symptom questionnaire.