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Robert Müller

Bio: Robert Müller is an academic researcher from Leibniz Institute of Photonic Technology. The author has contributed to research in topics: Magnetic nanoparticles & Nanoparticle. The author has an hindex of 22, co-authored 55 publications receiving 2483 citations. Previous affiliations of Robert Müller include Bundesanstalt für Materialforschung und -prüfung & University of Glasgow.


Papers
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TL;DR: In this paper, the specific loss power of magnetic nanoparticles for hyperthermia was investigated with respect to optimization of the SLP for application in tumour hyper-thermia and the dependence of the loss power on the mean particle size was studied over a broad size range from superparamagnetic up to multidomain particles.
Abstract: Loss processes in magnetic nanoparticles are discussed with respect to optimization of the specific loss power (SLP) for application in tumour hyperthermia. Several types of magnetic iron oxide nanoparticles representative for different preparation methods (wet chemical precipitation, grinding, bacterial synthesis, magnetic size fractionation) are the subject of a comparative study of structural and magnetic properties. Since the specific loss power useful for hyperthermia is restricted by serious limitations of the alternating field amplitude and frequency, the effects of the latter are investigated experimentally in detail. The dependence of the SLP on the mean particle size is studied over a broad size range from superparamagnetic up to multidomain particles, and guidelines for achieving large SLP under the constraints valid for the field parameters are derived. Particles with the mean size of 18 nm having a narrow size distribution proved particularly useful. In particular, very high heating power may be delivered by bacterial magnetosomes, the best sample of which showed nearly 1 kW g −1 at 410 kHz and 10 kA m −1 . This value may even be exceeded by metallic magnetic particles, as indicated by measurements on cobalt particles.

919 citations

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TL;DR: In this paper, the authors reviewed some pertinent research aimed at understanding surface nucleation from both qualitative and quantitative points of view, including surface quality, tips, cracks and scratches, foreign particles and surrounding atmosphere.
Abstract: In this paper we review some pertinent research aimed at understanding surface nucleation from both qualitative and quantitative points of view. The majority of quantitative studies discuss the crystal nucleation kinetics of soda-lime-silica glasses and alkali-free silicate (cordierite, anorthite and diopside) glasses. We emphasize the kinetics of surface nucleation and consider the effects of surface quality, tips, cracks and scratches, foreign particles and surrounding atmosphere on crystallization. Related nucleation mechanisms are discussed.

230 citations

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TL;DR: The results suggest that HBIG after OLT imposes a selection pressure on the S‐gene, and that mutations are one mechanism for reinfection while receiving H BIG.

192 citations

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TL;DR: The magnetic ex vivo characterization of the removed tumour tissue gave clear evidence for the immobilization of the particles in the tumours because the particlesIn the tumour showed the same magnetic behaviour as immobilized particles.
Abstract: When using magnetic nanoparticles as a heating source for magnetic particle hyperthermia it is of particular interest to know if the particles are free to move in the interstitial fluid or are fixed to the tumour tissue. The immobilization state determines the relaxation behaviour of the administered particles and thus their specific heating power. To investigate this behaviour, magnetic multicore nanoparticles were injected into experimentally grown tumours in mice and magnetic heating treatment was carried out in an alternating magnetic field (H = 25 kA m − 1, f = 400 kHz). The tested particles were well suited for magnetic heating treatment as they heated a tumour of about 100 mg by about 22 K within the first 60 s. Upon sacrifice, histological tumour examination showed that the particles form spots in the tissue with a mainly homogeneous particle distribution in these spots. The magnetic ex vivo characterization of the removed tumour tissue gave clear evidence for the immobilization of the particles in the tumour tissue because the particles in the tumour showed the same magnetic behaviour as immobilized particles. Therefore, the particles are not able to rotate and a temperature increase due to Brown relaxation can be neglected. To accurately estimate the heating potential of magnetic materials, the respective environments influencing the nanoparticle mobility status have to be taken into account.

175 citations

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TL;DR: In this paper, water-based suspensions of multicore nanoparticles were prepared by coating of the particles (synthesized by means of a modified alkaline precipitation method) with a carboxymethyldextran shell.

134 citations


Cited by
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Journal ArticleDOI
15 Feb 2017-Methods
TL;DR: TrackMate is an extensible platform where developers can easily write their own detection, particle linking, visualization or analysis algorithms within the TrackMate environment and is validated for quantitative lifetime analysis of clathrin-mediated endocytosis in plant cells.

2,356 citations

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TL;DR: Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,†.
Abstract: Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Universite ́ Paris-Sud XI, UMR CNRS 8612, Faculte ́ de Pharmacie, IFR 141, 5 rue Jean-Baptiste Cleḿent, F-92296 Chat̂enay-Malabry, France Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain ‡Pharmaceutical Sciences Department, Sanofi, 13 Quai Jules Guesdes, F-94403 Vitry-sur-Seine, France

1,705 citations

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TL;DR: Potential opportunities for the combination of hyperthermia-based therapy and controlled drug release paradigms--towards successful application in personalized medicine are portrayed.

1,380 citations

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TL;DR: This Letter demonstrates a significant increase in the efficiency of magnetic thermal induction by nanoparticles and finds that the therapeutic efficacy of these nanoparticles is superior to that of a common anticancer drug.
Abstract: The properties of core–shell nanoparticles can be tuned so that they efficiently convert radiation into heat, leading to therapeutic results that are competitive with commercial drug treatments.

1,164 citations

Journal ArticleDOI
TL;DR: In this review, the limitations and recent advances in the development of superparamagnetic iron oxide nanoparticles for hyperthermia are presented.

1,161 citations