R
Robert Nitsch
Researcher at University of Mainz
Publications - 184
Citations - 16791
Robert Nitsch is an academic researcher from University of Mainz. The author has contributed to research in topics: Hippocampal formation & Dentate gyrus. The author has an hindex of 67, co-authored 179 publications receiving 15642 citations. Previous affiliations of Robert Nitsch include University of Münster & Charité.
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Journal ArticleDOI
A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment.
Agnieszka Rybak,Heiko Fuchs,Lena Smirnova,Christine Brandt,Elena E. Pohl,Robert Nitsch,F. Gregory Wulczyn +6 more
TL;DR: It is demonstrated that the pluripotency factor Lin-28 binds the pre-let-7 RNA and inhibits processing by the Dicer ribonuclease in ES and EC cells, suggesting that let-7, mir-125 and lin-28 participate in an autoregulatory circuit that controls miRNA processing during NS-cell commitment.
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Regulation of miRNA expression during neural cell specification.
TL;DR: Noncoding miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development.
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OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
Simone A Fietz,Iva Kelava,Johannes Vogt,Michaela Wilsch-Bräuninger,Denise Stenzel,Jennifer L. Fish,Denis Corbeil,Axel Riehn,Wolfgang Distler,Robert Nitsch,Wieland B. Huttner +10 more
TL;DR: It is found that progenitors in the outer SVZ (OSVZ) of developing human neocortex retain features of radial glia, in contrast to rodent SVZ progensitors, which have limited proliferation potential.
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An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Sabrina M. Lehmann,Christina Krüger,Boyoun Park,Katja Derkow,Karen Rosenberger,Jan Baumgart,Thorsten Trimbuch,Gina D. Eom,Michael Hinz,David Kaul,Piet Habbel,Roland E. Kälin,Eleonora Franzoni,Agnieszka Rybak,Duong T. T. Nguyen,Rüdiger W. Veh,Olaf Ninnemann,Oliver Peters,Robert Nitsch,Frank L. Heppner,Douglas T. Golenbock,Eckart Schott,Hidde L. Ploegh,F. Gregory Wulczyn,Seija Lehnardt +24 more
TL;DR: The results suggest that microRNAs can function as signaling molecules and identify TLR7 as an essential element in a pathway that contributes to the spread of CNS damage.
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Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease.
TL;DR: It is suggested that PHF‐tau is able directly to induce neuronal damage in the AD brain, as the proteasome activity in human brains strongly correlated with the amount of co‐precipitated PHF-tau during immunoprecipitation of proteasomes.