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Robert P. Hanzlik
Researcher at University of Kansas
Publications - 150
Citations - 4889
Robert P. Hanzlik is an academic researcher from University of Kansas. The author has contributed to research in topics: Bromobenzene & Hydroxylation. The author has an hindex of 36, co-authored 150 publications receiving 4700 citations. Previous affiliations of Robert P. Hanzlik include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Quinone chemistry and toxicity
Journal ArticleDOI
Roles of key active-site residues in flavocytochrome P450 BM3
Michael A. Noble,Caroline S Miles,Stephen K Chapman,Dominikus A. Lysek,Angela C. Mackay,Graeme A Reid,Robert P. Hanzlik,Andrew W. Munro +7 more
TL;DR: Mutants F87G and F87Y not only exhibit increased Km and decreased kcat values for fatty acid oxidation, but also undergo an irreversible conversion process from a 'fast' to a 'slow' rate of substrate turnover.
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Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124
Douglas S. Auld,Scott Lovell,Natasha Thorne,Wendy A. Lea,David J. Maloney,Min Shen,Ganesha Rai,Kevin P. Battaile,Craig J. Thomas,Anton Simeonov,Robert P. Hanzlik,James Inglese +11 more
TL;DR: This study shows that FLuc inhibition and stabilization is the result of an inhibitory product formed during the FLuc-catalyzed reaction between its natural substrate, ATP, and PTC124, and demonstrates that formation of this novel MAI is absolutely dependent upon the precise positioning and reactivity of a key meta-carboxylate of PTC 124 within theFLuc active site.
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Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes
Heather Hajovsky,Gang Hu,Yakov M. Koen,Diganta Sarma,Wenqi Cui,David S. Moore,Jeff L. Staudinger,Robert P. Hanzlik +7 more
TL;DR: Improved understanding of the metabolism and covalent binding of TA and TASO facilitates the use of hepatocytes to prepare protein adducts for target protein identification and may help explain phenomena previously interpreted as "saturation toxicokinetics" in the in vivo metabolism and toxicity of TA.