R
Robert P. Martin
Researcher at Centre national de la recherche scientifique
Publications - 68
Citations - 3075
Robert P. Martin is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Transfer RNA & Mitochondrion. The author has an hindex of 32, co-authored 68 publications receiving 2962 citations. Previous affiliations of Robert P. Martin include University of Strasbourg.
Papers
More filters
Journal ArticleDOI
A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae
Nina Entelis,Irina Brandina,Piotr Kamenski,Igor A. Krasheninnikov,Robert P. Martin,Ivan Tarassov +5 more
TL;DR: The results indicate an alternative molecular chaperone function of glycolytic enzyme enolase in tRNA mitochondrial targeting, and propose a model suggesting that the cell exploits mitochondrial targeting of the enol enzyme in order to address the tRNA toward peri-mitochondrially synthesized preMsk1p.
Journal ArticleDOI
Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells
Olga Kolesnikova,Nina Entelis,Clarisse Jacquin-Becker,Francine Goltzene,Zofia M.A. Chrzanowska-Lightowlers,Robert N. Lightowlers,Robert P. Martin,Ivan Tarassov +7 more
TL;DR: These findings prove for the first time the functionality of imported tRNAs in human mitochondria in vivo and highlight the potential for exploiting the RNA import pathway to treat patients with mtDNA diseases.
Journal ArticleDOI
Suppression of Mutations in Mitochondrial DNA by tRNAs Imported from the Cytoplasm
Olga Kolesnikova,Nina S. Entelis,Nina S. Entelis,Hakim Mireau,Thomas D. Fox,Robert P. Martin,Ivan Tarassov +6 more
TL;DR: It is shown that cytoplasmic tRNAs with altered aminoacylation identity can be specifically targeted to the mitochondria and participate in mitochondrial translation and that human mitochondria are able to internalize yeast tRNA derivatives in vitro and that this import requires an essential yeast import factor.
Journal ArticleDOI
Import of nuclear deoxyribonucleic acid coded lysine-accepting transfer ribonucleic acid (anticodon C-U-U) into yeast mitochondria
Journal ArticleDOI
Mitochondrial import of a cytoplasmic lysine-tRNA in yeast is mediated by cooperation of cytoplasmic and mitochondrial lysyl-tRNA synthetases.
TL;DR: It is hypothesized that the cytosolic precursor form of the mitochondrial synthetase has a carrier function for translocation of the tRNA across the mitochondrial membranes, suggesting the need of additional factor(s) for tRNA import.