R
Robert Phelps
Researcher at Myriad Genetics
Publications - 5
Citations - 6151
Robert Phelps is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Positional cloning & Gene mapping. The author has an hindex of 4, co-authored 5 publications receiving 5919 citations.
Papers
More filters
Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
Comparison of the positional cloning methods used to isolate the BRCA1 gene
Keith D Harshman,Russell Bell,Judith Rosenthal,Harold Katcher,Yoshio MlKl,Jeff Swenson,Zahra Gholami,Cheryl Frye,Wei Ding,Priya Dayananth,Ken Eddington,Franklin H. Norris,Pamela K. Bristow,Robert Phelps,Thomas Haltier,Steven Stone,Daniel Shaffer,Steven Bayer,Charles E. Hussey,Thanh Tran,Katherine K. Richardson,Brad Dehoff,Mei Lai,Paul Robert Rosteck,Mark H. Skolnick,Mark H. Skolnick,Donna M Shattuck-Eidens,Alexander Kamb +27 more
TL;DR: An analysis of the efficiency and the sequences generated for each of the methods used to identify 45 candidate gene fragments (CGFs) from a 600 kb genomic region that contains the BRCA1 gene is presented.
Journal ArticleDOI
Localization of the VHR Phosphatase Gene and Its Analysis as a Candidate for BRCA1
Alexander Kamb,P. Andrew Futreal,Judith Rosenthal,Charles Cochran,Keith D Harshman,Qingyun Liu,Robert Phelps,Sean V. Tavtigian,Thanh Tran,Charles E. Hussey,Russell Bell,Yoshio Miki,Jeff Swensen,Maurine R. Hobbs,Jeffrey R. Marks,L. Michelle Bennett,J. Carl Barrett,Roger W. Wiseman,Donna M Shattuck-Eidens +18 more
TL;DR: The VH1-related human protein (VHR) gene was localized to human chromosome 17q21 in a region thought to contain the BRCA1 locus, a locus that confers susceptibility to breast and ovarian cancer and was screened in individuals with familial breast cancer and in sporadic breast tumor and breast cancer cell lines.
Journal ArticleDOI
Monitoring the efficacy of hybrid selection during positional cloning: the search for BRCA1.
T. Hattier,Russell Bell,Daniel Shaffer,Steven Stone,Robert Phelps,Sean V. Tavtigian,Mark H. Skolnick,Donna M Shattuck-Eidens,Alexander Kamb +8 more
TL;DR: This work uses hybrid selection to screen a 600-kb region that includes the BRCA1 gene and introduces simple parameters that serve as measures of important aspects of the hybrid selection process in the context of positional cloning.