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Robert Tjian
Researcher at University of California, Berkeley
Publications - 289
Citations - 59502
Robert Tjian is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Transcription (biology) & Transcription factor. The author has an hindex of 118, co-authored 280 publications receiving 56288 citations. Previous affiliations of Robert Tjian include Howard Hughes Medical Institute & University of California, San Francisco.
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Journal ArticleDOI
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins
Pamela J. Mitchell,Robert Tjian +1 more
TL;DR: This review summarizes recent studies that define structural domains for DNA binding and transcriptional activation functions in sequence-specific transcription factors in mammalian DNA binding transcription factors.
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Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
TL;DR: It is demonstrated that multiple synthetic copies of the consensus AP-1-binding site can act as TPA-inducible enhancers in various plasmid constructs after transfection into HeLa cells, suggesting that AP- 1 is a transcription factor that functions by interacting with a specific enhancer element, and that its activities may be modulated by treatment of cells with TPA.
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Transcription regulation and animal diversity
Michael Levine,Robert Tjian +1 more
TL;DR: Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrates have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones.
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Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif
Albert J. Courey,Robert Tjian +1 more
TL;DR: Drosophila tissue culture cells provide an Sp1-deficient background and have been used in a complementation assay to identify functional domains of human transcription factor Sp1, and it is proposed that these glutamine-rich domains represent a novel structural motif for transcriptional activation.
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Human Proto-Oncogene c-jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1
TL;DR: It is demonstrated that the proto-oncogene product of c-jun interacts directly with specific target DNA sequences to regulate gene expression, and therefore it may now be possible to identify genes under the control ofc-jun that affect cell growth and neoplasia.