R
Robert W. Taylor
Researcher at Newcastle University
Publications - 771
Citations - 39340
Robert W. Taylor is an academic researcher from Newcastle University. The author has contributed to research in topics: Mitochondrial DNA & Mitochondrial disease. The author has an hindex of 87, co-authored 722 publications receiving 34128 citations. Previous affiliations of Robert W. Taylor include University of Newcastle & Radboud University Nijmegen.
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Mitochondrial dna mutations in human disease
TL;DR: This review explores the advances that have been made and the areas in which future progress is likely in understanding basic mitochondrial genetics and the relationship between inherited mutations and disease phenotypes, and in identifying acquired mtDNA mutations in both ageing and cancer.
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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.
Andreas Bender,Kim J. Krishnan,Christopher Morris,Geoffrey A. Taylor,Amy K. Reeve,Robert H. Perry,Evelyn Jaros,Joshua S Hersheson,Joanne Betts,Thomas Klopstock,Robert W. Taylor,Douglass M. Turnbull +11 more
TL;DR: It is shown that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA, suggesting that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease.
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Mitochondrial DNA mutations in human disease.
TL;DR: This review considers the basic principles of mitochondrial genetics which govern both the behaviour and investigation of pathogenic mtDNA mutations summarizing recent advances, and an assessment of the ongoing debate into the role of somatic mt DNA mutations in neurodegenerative disease, ageing and cancer.
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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease.
Grainne S. Gorman,Andrew M. Schaefer,Yi Ng,Nicholas Gomez,Emma L. Blakely,Charlotte L. Alston,Catherine Feeney,Rita Horvath,Patrick Yu-Wai-Man,Patrick F. Chinnery,Robert W. Taylor,Douglass M. Turnbull,Robert McFarland +12 more
TL;DR: In this paper, the authors evaluated the minimum prevalence of symptomatic nuclear DNA mutations and symptomatic and asymptomatic mtDNA mutations causing mitochondrial diseases, and found that the mtDNA mutation rate was 1 in 5,000 (20 per 100,000), comparable with the previously published prevalence rates.
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Mitochondrial DNA mutations and human disease
TL;DR: The unique features of mitochondrial genetics are outlined before detailing the diseases and their genetic causes, focusing specifically on primary mtDNA genetic defects.