R
Roberto Romero
Researcher at National Institutes of Health
Publications - 1622
Citations - 121818
Roberto Romero is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Amniotic fluid & Pregnancy. The author has an hindex of 151, co-authored 1516 publications receiving 108321 citations. Previous affiliations of Roberto Romero include University of Michigan & Weizmann Institute of Science.
Papers
More filters
Journal ArticleDOI
The role of cervical cerclage in obstetric practice: Can the patient who could benefit from this procedure be identified?
TL;DR: The definition, the clinical ascertainment, efforts to develop an objective method of diagnosis, as well as the nature of cervical disease leading to spontaneous mid-trimester spontaneous abortion and preterm delivery are reviewed.
Journal ArticleDOI
Normal and abnormal transformation of the spiral arteries during pregnancy.
Jimmy Espinoza,Roberto Romero,Yeon Mee Kim,Juan Pedro Kusanovic,Sonia S. Hassan,Offer Erez,Francesca Gotsch,Nandor Gabor Than,Zoltán Papp,Chong Jai Kim +9 more
TL;DR: The anatomy and physiology of the uterine circulation is reviewed, with emphasis on the remodeling of spiral arteries during normal pregnancy, and the timing and anatomical pathways of trophoblast invasion of the spiral arteries.
Journal ArticleDOI
A Single Nucleotide Polymorphism in the Matrix Metalloproteinase-1 (MMP-1) Promoter Influences Amnion Cell MMP-1 Expression and Risk for Preterm Premature Rupture of the Fetal Membranes
Toshio Fujimoto,Samuel Parry,Margrit Urbanek,Mary D. Sammel,George A. Macones,Helena Kuivaniemi,Roberto Romero,Jerome F. Strauss +7 more
TL;DR: It is concluded that the 2G allele has stronger promoter activity in amnion cells, that it confers increased responsiveness of amnions cells to stimuli that induce MMP-1, and that this polymorphism contributes to the risk of PPROM.
Journal ArticleDOI
Complement Activation Triggers Metalloproteinases Release Inducing Cervical Remodeling and Preterm Birth in Mice
TL;DR: The studies show that C5a-C5aR interaction is required for MMP-9 release from macrophages, and the cervical remodeling that leads to PTD, and complement inhibition and supplementation with progesterone may be good therapeutic options to prevent this serious pregnancy complication.
Journal ArticleDOI
Prevention of Preeclampsia with Low-Dose Aspirin in Healthy, Nulliparous Pregnant Women
Baha M. Sibai,S.N. Cartis,Elizabeth Thom,M. Kelbanoff,Donald McNellis,L. Rocco,Richard H. Paul,Roberto Romero,Frank R. Witter,Mortimer G. Rosen,Richard Depp,S. Godfrey,R. Chao,T. Gordon,J.D. Greene,S. Tannenbaum,R.C. Cefalo,M. Cotroneo,C. Walla +18 more
TL;DR: Treatment with aspirin reduced the incidence of preeclampsia among women at high risk for this complication and the effect of aspirin on maternal and neonatal morbidity was evaluated.