Robin M. Murray

TL;DR: A perturbed maturational relationship among brain regions underlies poor treatment response in first-episode psychosis and the information obtained from gyrification-based connectomes can be harnessed for prospectively predicting treatment response and prognosis in psychosis.

TL;DR: The preliminary evidence suggests that sertindole’s decreased tendency to induce EPS at clinically therapeutic doses is not due to limited occupancy of striatal D2 receptors in vivo, and as is the case for risperidone, patients are protected from EPS by some other intrinsic effect of the drug.

TL;DR: These findings provide the first large-scale evidence that FEP patients with a history of daily use of high-potency cannabis present with more positive and less negative symptoms, compared with those who never used cannabis or used low-potencies types.

TL;DR: Bipolar disorder was significantly associated with a diminished P50 suppression ratio and decreased C–T amplitude difference and shared genetic factors were the main source of these associations.

TL;DR: In this paper, the authors suggest that when antipsychotics are reduced, it should be done gradually (over months or years) and in a hyperbolic manner (to reduce D2 blockade "evenly"): i.e., reducing by one quarter (or one half) of the most recent dose of antipsychotic, equivalent approximately to a reduction of 5 (or 10) percentage points of its D2 receptor blockade, sequentially (so that reductions become smaller and smaller in size as total dose decreases), at intervals of 3-6 months, titrated to individual tolerance