R
Robin M. Murray
Researcher at King's College London
Publications - 1583
Citations - 128883
Robin M. Murray is an academic researcher from King's College London. The author has contributed to research in topics: Psychosis & Schizophrenia. The author has an hindex of 171, co-authored 1539 publications receiving 116362 citations. Previous affiliations of Robin M. Murray include University of Cambridge & National Institutes of Health.
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Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis.
Monica Aas,Paola Dazzan,Valeria Mondelli,Timothea Toulopoulou,A. Reichenberg,M. Di Forti,Helen L. Fisher,Rowena Handley,Nilay Hepgul,Tiago Reis Marques,A Miorelli,Heather Taylor,Manuela Russo,Benjamin D.R. Wiffen,Andrew Papadopoulos,Katherine J. Aitchison,Craig Morgan,Robin M. Murray,Carmine M. Pariante +18 more
TL;DR: Data support a role for the HPA axis, as measured by cortisol awakening response, in modulating cognitive function in patients with psychosis; however, this association does not seem to be related to the increased exposure to psychosocial stressors described in these patients.
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Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients.
Nilay Hepgul,Carmine M. Pariante,Salvatore Dipasquale,Marta DiForti,Heather Taylor,Tiago Reis Marques,Craig Morgan,Paola Dazzan,Robin M. Murray,Valeria Mondelli +9 more
Abstract: Background The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls. Method Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors. Results Patients with childhood maltreatment had higher BMI [25.0 (s.e.=0.6) kg/m2] and C-reactive protein (CRP) levels [1.1 (s.e.=0.6) mg/dl] when compared with healthy controls [23.4 (s.e.=0.4) kg/m2, p=0.030 and 0.2 (s.e.=0.1) mg/dl, p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (s.e.=0.6) kg/m2, p=0.07] or CRP levels [0.5 (s.e.=0.2) mg/dl, p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F 2,58=3.6, p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue. Conclusions Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.
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Distribution of symptom dimensions across Kraepelinian divisions.
Dimitris Dikeos,Harvey Wickham,Colm McDonald,Muriel Walshe,Thordur Sigmundsson,Elvira Bramon,Anton Grech,Timothea Toulopoulou,Robin M. Murray,Pak C. Sham +9 more
TL;DR: Investigation of the structure of dimensions in psychosis foundMania was the best discriminator between schizophrenia and affective psychosis; the negative factor was strongly correlated with poor premorbid functioning, insidious onset and worse course.
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The clinical characterization of the patient with primary psychosis aimed at personalization of management
Mario Maj,Jim van Os,Jim van Os,Jim van Os,Marc De Hert,Marc De Hert,Wolfgang Gaebel,Silvana Galderisi,Michael F. Green,Michael F. Green,Sinan Guloksuz,Sinan Guloksuz,Philip D. Harvey,Peter B. Jones,Dolores Malaspina,Patrick D. McGorry,Jouko Miettunen,Jouko Miettunen,Robin M. Murray,Keith H. Nuechterlein,Victor Peralta,Graham Thornicroft,Ruud van Winkel,Ruud van Winkel,Ruud van Winkel,Joseph Ventura +25 more
TL;DR: In this paper, the authors describe the salient domains that should be considered in the characterization of the individual patient with primary psychosis aimed at personalization of management, and provide simple assessment instruments that could be considered for use in clinical practice and included in standardized decision tools.
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A genetic and environmental analysis of a twin family study of alcohol use, anxiety, and depression.
TL;DR: This study illustrates that data from twins and their relatives which includes information on cohabitation history might distinguish shared genes and shared environment as causes of familial aggregation in twin family data.