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Robyn M. Sutherland
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 62
Citations - 2239
Robyn M. Sutherland is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 24, co-authored 60 publications receiving 2048 citations. Previous affiliations of Robyn M. Sutherland include University of Sydney & University of Pennsylvania.
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Journal ArticleDOI
Cell-associated ovalbumin is cross-presented much more efficiently than soluble ovalbumin in vivo.
Ming Li,Gayle M. Davey,Robyn M. Sutherland,Christian Kurts,Andrew M. Lew,Claire E Hirst,Francis R. Carbone,William R. Heath +7 more
TL;DR: Data presented, which represent the first quantitative in vivo analysis of cross-presentation, show that cell-associated OVA is very efficiently presented via the class I pathway.
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CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose
Christian Kurts,Robyn M. Sutherland,Gayle M. Davey,Ming Li,Andrew M. Lew,Effrossini Blanas,Francis R. Carbone,Jacques F. A. P. Miller,William R. Heath +8 more
TL;DR: It is demonstrated that the concentration of self antigen determines which mechanism operates, and the immune system uses two strategies to avoid CD8(+) T cell-mediated autoimmunity: for high dose antigens, it deletes autoreactive T cells, whereas for lower doses, it relies on ignorance.
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Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
Julia M. Marchingo,Julia M. Marchingo,Andrey Kan,Andrey Kan,Robyn M. Sutherland,Robyn M. Sutherland,Ken R. Duffy,Cameron J. Wellard,Cameron J. Wellard,Gabrielle T. Belz,Gabrielle T. Belz,Andrew M. Lew,Andrew M. Lew,Mark R. Dowling,Mark R. Dowling,Mark R. Dowling,Susanne Heinzel,Susanne Heinzel,Philip D. Hodgkin,Philip D. Hodgkin +19 more
TL;DR: In this article, the authors report that T cell receptor (TCR) and costimulatory signals imprint an early, cell-intrinsic, division fate, whereby cells effectively count through generations before returning automatically to a quiescent state.
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Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells
Susan Johnson,Susan Johnson,Yifan Zhan,Robyn M. Sutherland,Adele M. Mount,Adele M. Mount,Sammy Bedoui,Jamie L. Brady,Emma M. Carrington,Lorena E. Brown,Gabrielle T. Belz,William R. Heath,Andrew M. Lew +12 more
TL;DR: CD40L upregulation on DCs promoted optimal priming of CD8(+) T cells without CD4(+) T cells, providing a mechanism by which pathogens may elicit helper-independent CTL immunity.
Journal ArticleDOI
BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
Emma M. Carrington,Ingela B Vikstrom,Amanda Light,Robyn M. Sutherland,Sarah L. Londrigan,Kylie D. Mason,David C.S. Huang,Andrew M. Lew,David M. Tarlinton +8 more
TL;DR: An insight is provided into the selective mechanisms of immune cell survival and how this selectivity avails a different strategy for immune modulation.