R
Rocio Chapela
Researcher at National Autonomous University of Mexico
Publications - 51
Citations - 4039
Rocio Chapela is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Population & Asthma. The author has an hindex of 31, co-authored 51 publications receiving 3782 citations.
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Journal ArticleDOI
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
Andrés Moreno-Estrada,Christopher R. Gignoux,Juan Carlos Fernández-López,Fouad Zakharia,Martin Sikora,Alejandra V. Contreras,Victor Acuña-Alonzo,Karla Sandoval,Celeste Eng,Sandra Romero-Hidalgo,Patricia Ortiz-Tello,Victoria Robles,Eimear E. Kenny,Ismael Nuño-Arana,Rodrigo Barquera-Lozano,Gastón Macín-Pérez,Julio Granados-Arriola,Scott Huntsman,Joshua Galanter,Marc Via,Jean G. Ford,Rocio Chapela,William Rodriguez-Cintron,J.R. Rodriguez-Santana,Isabelle Romieu,Juan José Luis Sienra-Monge,Blanca E. del Rio Navarro,Stephanie J. London,Andres Ruiz-Linares,Rodrigo García-Herrera,Karol Estrada,Alfredo Hidalgo-Miranda,Gerardo Jimenez-Sanchez,Alessandra Carnevale,Xavier Soberón,Samuel Canizales-Quinteros,Héctor Rangel-Villalobos,Irma Silva-Zolezzi,Esteban G. Burchard,Carlos Bustamante +39 more
TL;DR: Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function.
Journal ArticleDOI
Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological research.
Esteban G. Burchard,Luisa N. Borrell,Shweta Choudhry,Mariam Naqvi,Hui Ju Tsai,Jose R. Rodriguez-Santana,Rocio Chapela,Scott D. Rogers,Rui Mei,William Rodriguez-Cintron,Jose F. Arena,Rick A. Kittles,Eliseo J. Pérez-Stable,Elad Ziv,Neil Risch,Neil Risch +15 more
TL;DR: The historical events that led to the formation of contemporary Latino populations are reviewed and results from recent genetic and clinical studies are used to illustrate the unique opportunity Latino groups offer for studying the interaction between racial, genetic, and environmental contributions to disease occurrence and drug response.
Journal ArticleDOI
Exposure to biomass smoke and chronic airway disease in Mexican women. A case-control study.
Rogelio Pérez-Padilla,Justino Regalado,Sverre Vedal,Peter D. Paré,Rocio Chapela,Raúl H Sansores,Moisés Selman +6 more
TL;DR: A causal role of domestic wood smoke exposure in chronic bronchitis and chronic airflow obstruction is support by a case-control study performed in women older than 40 yr of age.
Journal ArticleDOI
ORMDL3 gene is associated with asthma in three ethnically diverse populations.
Joshua Galanter,Shweta Choudhry,Celeste Eng,Sylvette Nazario,Jose R. Rodriguez-Santana,Jesus Casal,Alfonso Torres-Palacios,Jorge Salas,Rocio Chapela,H. Geoffrey Watson,Kelley Meade,Michael A. LeNoir,William Rodríguez-Cintrón,Pedro C. Avila,Esteban G. Burchard +14 more
TL;DR: The results confirm that the ORMDL3 locus is a risk factor for asthma in ethnically diverse populations, however, inconsistent SNP-level results suggest that further studies will be needed to determine the mechanism by which OR MDL3 predisposes to asthma.
Journal ArticleDOI
Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas
Joshua Galanter,Juan Carlos Fernández-López,Christopher R. Gignoux,Jill S. Barnholtz-Sloan,Ceres Fernandez-Rozadilla,Marc Via,Alfredo Hidalgo-Miranda,Alejandra V. Contreras,Laura Uribe Figueroa,Paola Raska,Gerardo Jimenez-Sanchez,Irma Silva Zolezzi,María Dolores Torres,Clara Ruiz–Ponte,Y. Ruiz,Antonio Salas,Elizabeth A. Nguyen,Celeste Eng,Lisbeth Borjas,William Zabala,William Zabala,Guillermo Barreto,Fernando Rondóo González,A. Ibarra,Patricia Taboada,L. Porras,L. Porras,F.L. Moreno,Abigail W. Bigham,Gerardo Gutiérrez,Tom D. Brutsaert,Fabiola León-Velarde,Lorna G. Moore,Enrique Vargas,Miguel Cruz,Jorge Escobedo,Jose R. Rodriguez-Santana,William Rodriguez-Cintron,Rocio Chapela,Jean G. Ford,Carlos Bustamante,Daniela Seminara,Mark D. Shriver,Elad Ziv,Esteban G. Burchard,Robert W. Haile,Esteban J. Parra,Angel Carracedo +47 more
TL;DR: A panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.