R
Roderick T. Bronson
Researcher at Harvard University
Publications - 689
Citations - 115449
Roderick T. Bronson is an academic researcher from Harvard University. The author has contributed to research in topics: Carcinogenesis & Cancer. The author has an hindex of 169, co-authored 679 publications receiving 107702 citations. Previous affiliations of Roderick T. Bronson include Massachusetts Institute of Technology & University of Düsseldorf.
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Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts
Toshihisa Komori,Hideshi Yagi,Shintaro Nomura,Akira Yamaguchi,Koichi Sasaki,Kenji Deguchi,Y Shimizu,Roderick T. Bronson,Y.-H Gao,Masahiko Inada,Makoto Sato,R Okamoto,Yukihiko Kitamura,Shusaku Yoshiki,Tadamitsu Kishimoto +14 more
TL;DR: The data suggest that both intramembranous and endochondral ossification were completely blocked, owing to the maturational arrest of osteoblasts in the mutant mice, and demonstrate that Cbfa1 plays an essential role in osteogenesis.
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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
Mark S. Anderson,Emily S. Venanzi,Ludger Klein,Zhibin Chen,Stuart P. Berzins,Shannon J. Turley,Harald von Boehmer,Roderick T. Bronson,Andrée Dierich,Christophe Benoist,Diane Mathis +10 more
TL;DR: Aire-deficient thymic medullary epithelial cells showed a specific reduction in ectopic transcription of genes encoding peripheral antigens, highlighting the importance of thymically imposed “central” tolerance in controlling autoimmunity.
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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
Annie Yang,Ronen Schweitzer,Deqin Sun,Mourad Kaghad,Nancy Walker,Roderick T. Bronson,Clifford J. Tabin,Arlene H. Sharpe,Daniel Caput,Christopher P. Crum,Frank McKeon +10 more
TL;DR: It is reported that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development, and results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelialDevelopment and morphogenesis.
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Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
Carla F. Kim,Erica L. Jackson,Amber Woolfenden,Sharon Lawrence,Imran Babar,Sinae Vogel,Denise Crowley,Roderick T. Bronson,Tyler Jacks +8 more
TL;DR: Although bronchiolar cells and alveolar cells are proposed to be the precursor cells of adenocarcinoma, this work points to bronchioalveolar stem cells as the putative cells of origin for this subtype of lung cancer.
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Tumor spectrum analysis in p53-mutant mice.
Tyler Jacks,Lee Remington,Bart O. Williams,Earlene M. Schmitt,Shlomit Halachmi,Roderick T. Bronson,Robert A. Weinberg +6 more
TL;DR: It is reaffirm that p53 function is not required for normal mouse development and conclude that p 53 status can strongly influence tumor latency and tissue distribution.