Rodolfo Iuliano

TL;DR: A unique microRNA signature is associated with prognostic factors and disease progression in CLL, and a germ-line mutation in the miR-16-1-miR-15a primary precursor caused low levels of microRNA expression in vitro and in vivo and was associated with deletion of the normal allele.

TL;DR: The data indicate that IL-18 up-regulation is a feature of CD and suggest thatIL-18 may contribute to the local immunoinflammatory response in CD.

TL;DR: A genetic flaw was reported that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from four subjects with insulin resistance and type 2 diabetes.

TL;DR: The data support a mechanistic link between HR and DNA methylation and suggest thatDNA methylation in eukaryotes marks homologous recombined segments.

TL;DR: It is demonstrated that HMGI-Y plays significant molecular roles in the transcriptional activities of these factors in the context of the IR gene and provides concordant support for the hypothesis that, in affected individuals, a putative defect in these nuclear proteins may cause decreased IR expression with subsequent impairment of insulin signaling and action.