R
Roel Goldschmeding
Researcher at Utrecht University
Publications - 254
Citations - 13544
Roel Goldschmeding is an academic researcher from Utrecht University. The author has contributed to research in topics: CTGF & Fibrosis. The author has an hindex of 62, co-authored 245 publications receiving 12186 citations. Previous affiliations of Roel Goldschmeding include University of Michigan & University of Amsterdam.
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Journal ArticleDOI
Expression of connective tissue growth factor in human renal fibrosis
Yasuhiko Ito,Jan Aten,Richard J. Bende,Barry S. Oemar,Ton J. Rabelink,Jan J. Weening,Roel Goldschmeding +6 more
TL;DR: The results indicate that CTGF may be a common growth factor involved in renal fibrosis, and an increase in the number of cells expressing CTGF mRNA was observed at sites of chronic tubulointerstitial damage, which correlated with the degree of damage.
Journal ArticleDOI
Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1
Jeroen P. Roose,Gerwin Huls,Moniek van Beest,Petra Moerer,Karin van der Horn,Roel Goldschmeding,Ton Logtenberg,Hans Clevers +7 more
TL;DR: Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells.
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Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.
Roel Goldschmeding,C. E. Van Der Schoot,D. Ten Bokkel Huinink,C. E. Hack,M. E. Van Den Ende,Cees G. M. Kallenberg,A. E. G. K. Von Dem Borne +6 more
TL;DR: It is demonstrated that in some perinuclear staining (P-ANCA) patients' sera autoantibodies against other myeloid lysosomal enzymes can be detected, such as antimyeloperoxidase and antielastase.
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Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?
TL;DR: Outlining the mechanisms that underlie CTGF gene regulation in normal and fibrotic cells, might help design of future intervention strategies aiming at targeted specific interference with CTGF expression at sites of progressive fibrosis.
Journal ArticleDOI
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy
Koert M. Dolman,A. E. G. Kr. von dem Borne,Roel Goldschmeding,Rob Gans,Ajm Donker,Th.J. Vervaat,G. Zevenbergen,D. Maingay,R. E. Nikkels +8 more
TL;DR: Antineutrophil cytoplasmic antibodies (ANCA) have been described in association with several vasculitic disorders, such as vasculitis associated with propylthiouracil therapy as mentioned in this paper.