R
Roger A. Barker
Researcher at University of Cambridge
Publications - 661
Citations - 47351
Roger A. Barker is an academic researcher from University of Cambridge. The author has contributed to research in topics: Parkinson's disease & Huntington's disease. The author has an hindex of 101, co-authored 620 publications receiving 39728 citations. Previous affiliations of Roger A. Barker include Cognition and Brain Sciences Unit & Lund University.
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Journal ArticleDOI
RNA velocity of single cells
Gioele La Manno,Gioele La Manno,Ruslan A. Soldatov,Amit Zeisel,Amit Zeisel,Emelie Braun,Emelie Braun,Hannah Hochgerner,Hannah Hochgerner,Viktor Petukhov,Viktor Petukhov,Katja Lidschreiber,Maria Eleni Kastriti,Peter Lönnerberg,Peter Lönnerberg,Alessandro Furlan,Jean Fan,Lars E. Borm,Lars E. Borm,Zehua Liu,David van Bruggen,Jimin Guo,Xiaoling He,Roger A. Barker,Erik Sundström,Gonçalo Castelo-Branco,Patrick Cramer,Patrick Cramer,Igor Adameyko,Sten Linnarsson,Sten Linnarsson,Peter V. Kharchenko +31 more
TL;DR: It is shown that RNA velocity—the time derivative of the gene expression state—can be directly estimated by distinguishing between unspliced and spliced mRNAs in common single-cell RNA sequencing protocols, and expected to greatly aid the analysis of developmental lineages and cellular dynamics, particularly in humans.
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Diagnostic Criteria for Mild Cognitive Impairment in Parkinson’s Disease: Movement Disorder Society Task Force Guidelines
Irene Litvan,Jennifer G. Goldman,Alexander I. Tröster,Ben Schmand,Daniel Weintraub,Ronald C. Petersen,Brit Mollenhauer,Charles H. Adler,Karen Marder,Caroline H. Williams-Gray,Dag Aarsland,Jaime Kulisevsky,Maria C. Rodriguez-Oroz,David J. Burn,Roger A. Barker,Murat Emre +15 more
TL;DR: These diagnostic criteria will support future research efforts to identify at the earliest stage those PD patients at increased risk of progressive cognitive decline and dementia who may benefit from clinical interventions at a predementia stage.
Journal ArticleDOI
A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
Claire D. Clelland,Minee L. Choi,Carola Romberg,Gregory D. Clemenson,Alexandra M. C. Fragniere,P. Tyers,Sebastian Jessberger,Lisa M. Saksida,Roger A. Barker,Fred H. Gage,Timothy J. Bussey +10 more
TL;DR: Using adult mice in which hippocampal neurogenesis was ablated, this work found specific impairments in spatial discrimination with two behavioral assays: a spatial navigation radial arm maze task and a spatial, but non-navigable, task in the mouse touch screen.
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Enhanced or Impaired Cognitive Function in Parkinson's Disease as a Function of Dopaminergic Medication and Task Demands
TL;DR: DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry, which is relatively spared of DA loss in PD.
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Evolution of cognitive dysfunction in an incident Parkinson's disease cohort
TL;DR: This work clarifies the profile of cognitive dysfunction in early PD and demonstrates that the dementing process in this illness is heralded by both postural and gait dysfunction and cognitive deficits with a posterior cortical basis, reflecting probable non-dopaminergic cortical Lewy body pathology.