R
Roger Bouillon
Researcher at Katholieke Universiteit Leuven
Publications - 750
Citations - 66595
Roger Bouillon is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Vitamin D and neurology & vitamin D deficiency. The author has an hindex of 121, co-authored 735 publications receiving 62021 citations. Previous affiliations of Roger Bouillon include Catholic University of Leuven.
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Journal ArticleDOI
Intensive Insulin Therapy in Critically Ill Patients
Greet Van den Berghe,Pieter Wouters,Frank Weekers,Charles Verwaest,Frans Bruyninckx,Miet Schetz,Dirk Vlasselaers,Patrick Ferdinande,Peter Lauwers,Roger Bouillon +9 more
TL;DR: Intensive insulin therapy to maintain blood glucose at or below 110 mg per deciliter reduces morbidity and mortality among critically ill patients in the surgical intensive care unit.
Journal ArticleDOI
Intensive insulin therapy in the medical ICU.
Greet Van den Berghe,Alexander Wilmer,Greet Hermans,Wouter Meersseman,Pieter Wouters,Ilse Milants,Eric Van Wijngaerden,Herman Bobbaers,Roger Bouillon +8 more
TL;DR: Intensive insulin therapy significantly reduced morbidity but not mortality among all patients in the medical ICU, and the risk of subsequent death and disease was reduced in patients treated for three or more days.
Journal ArticleDOI
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Roger Bouillon,Geert Carmeliet,Lieve Verlinden,Evelyne van Etten,Annemieke Verstuyf,Hilary F. Luderer,Liesbet Lieben,Chantal Mathieu,Marie B. Demay +8 more
TL;DR: The precise mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D], can now be better evaluated by critical analysis of mice with engineered deletion of the Vitamin D receptor (VDR).
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An overview of real-time quantitative PCR: applications to quantify cytokine gene expression.
Annapaula Giulietti,Lutgart Overbergh,Dirk Valckx,Brigitte Decallonne,Roger Bouillon,Chantal Mathieu +5 more
TL;DR: The real-time RT-PCR technique is very accurate and sensitive, allows a high throughput, and can be performed on very small samples; therefore it is the method of choice for quantification of cytokine profiles in immune cells or inflamed tissues.
Journal ArticleDOI
Outcome benefit of intensive insulin therapy in the critically ill: Insulin dose versus glycemic control.
Greet Van den Berghe,Pieter Wouters,Roger Bouillon,Frank Weekers,Charles Verwaest,Miet Schetz,Dirk Vlasselaers,Patrick Ferdinande,Peter Lauwers +8 more
TL;DR: Normoglycemia was safely reached within 24 hrs and maintained during intensive care by using insulin titration guidelines, and metabolic control, as reflected by normoglycesmia, rather than the infused insulin dose per se, was related to the beneficial effects of intensive insulin therapy.