R
Roger Guillemin
Researcher at Salk Institute for Biological Studies
Publications - 228
Citations - 31156
Roger Guillemin is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Somatostatin & Pituitary gland. The author has an hindex of 89, co-authored 228 publications receiving 30865 citations. Previous affiliations of Roger Guillemin include Baylor University.
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Journal ArticleDOI
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Paul Brazeau,Wylie Vale,Roger Burgus,Nicholas Ling,Madalyn Butcher,Jean Rivier,Roger Guillemin +6 more
TL;DR: A peptide has been isolated from ovine hypothalamus which, at 1 x 10-9M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats.
Journal ArticleDOI
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland
Roger Guillemin,Therese Vargo,Jean Rossier,Scott Minick,Nicholas Ling,Catherine Rivier,Wylie Vale,Floyd E. Bloom +7 more
TL;DR: Both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin in response to acute stress or long-term adrenalectomy.
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Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.
Roger Guillemin,Paul Brazeau,Peter Bohlen,Frederick Esch,Nicholas Ling,William B. Wehrenberg +5 more
TL;DR: A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly and has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone.
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Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
Nicholas Ling,Shao-Yao Ying,Naoto Ueno,Shunichi Shimasaki,Frederick Esch,Mari Hotta,Roger Guillemin +6 more
TL;DR: It is proposed that the FSH-releasing substance, which is active in picomolar concentrations, is a heterodimeric protein composed of the two β-subunits of inhibins A and B linked by interchain disulphide bond(s).
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Basic fibroblast growth factor induces angiogenesis in vitro.
TL;DR: It is shown that highly purified basic pituitary FGF can induce capillary endothelial cells to invade a three-dimensional collagen matrix and to organize themselves to form characteristic tubules that resemble blood capillaries.