Roger Pai

TL;DR: Apo2L may have potent anticancer activity without significant toxicity toward normal tissues, and cooperated synergistically with the chemotherapeutic drugs 5-fluorouracil or CPT-11, causing substantial tumor regression or complete tumor ablation.

TL;DR: These findings not only provide a novel insight into the pathogenesis of the transplant-related atherosclerosis, but also point to a new therapeutic strategy that involves targeting of homing, differentiation and proliferation of putative smooth-muscle progenitor cells derived from the recipient.

TL;DR: It is suggested that DR5 may contribute more than DR4 to Apo2L/TRAIL-induced apoptosis in cancer cells that express both death receptors, which would suggest that the relative contribution of DR4 and DR5 to ligand- induced apoptosis is unknown.

TL;DR: During the characterization of a recombinant humanized monoclonal antibody, electrospray mass spectrometric analysis suggested that the light chain was highly glycated, and sequence alignments and computer modeling suggest that the unusually high level of glycation of lysine residue 49 is due to a spatial proximity effect in catalyzing the Amadori rearrangement by aspartic acid residue 31 in the CDR1 on the lightchain.

TL;DR: In this paper, the methods of making Apo-2 ligand and formulations of Apo 2 ligand using divalent metal ions are provided, such as zinc and cobalt, which improve ligand trimer formation and stability.