Roger Stupp

TL;DR: Transcriptome-based classification of medulloblastoma has delineated four variants that might now be candidate diseases in which to explore novel targeted agents, and large-scale molecular profiling approaches have identified new mutations in gliomas, but these molecular approaches cannot yet predict patients' benefit from therapeutic interventions.

TL;DR: A pooled analysis of European Organization for Research and Treatment of Cancer trials on recurrent glioblastoma to validate existing clinical prognostic factors, identify new markers, and derive new predictions for overall survival (OS) and progression free survival (PFS).

TL;DR: Week 4 FDG-PET is useful for early assessment of treatment response and for the prediction of clinical outcome, and offers opportunities to individualize and optimize patient therapy.

TL;DR: In this paper, the authors identify ATG4B as a substrate of mammalian sterile20-like kinase (STK) 26/MST4, which stimulates autophagocyte activity and increases autophagic flux.

TL;DR: It is concluded that mismatch repair and BRAF mutation status are associated with the formation of TLS in nmCRC, which follows sequential maturation steps, culminating in germinal center formation, and this maturation process harbors important prognostic information on the risk of disease recurrence.