Roger Stupp

TL;DR: It is found that, at clinically relevant concentrations, cilengitide induces detachment in some but not all glioma cell lines, while the effect on cell viability is modest, and suggests that the beneficial clinical effects derived from cilENGitide in vivo may arise from altered perfusion, which promotes temozolomide delivery toglioma cells.

TL;DR: Analysis of recurrence patterns revealed no difference between the groups in the size of the recurrent tumor or in the differential effect on the distance of the recurrences from the preoperative tumor location, and the data show the feasibility of groupwise recurrence pattern analysis.

TL;DR: Despite the lack of high-level evidence data, the use of anticonvulsants devoid of pharmacokinetic interactions should be recommended in patients with epilepsy symptomatic of brain tumors.

TL;DR: Co-evolution and interaction between gene copy gain, associated with a gain of chromosome 7, and additional epigenetic alterations as key mechanisms triggering a coordinated, but inappropriate, HOX transcriptional program in glioblastoma are proposed.

TL;DR: The benefit of temozolomide chemotherapy is restricted to patients whose tumors have a methylated methylguanine methyltransferase gene promotor and are thus unable to repair some of the chemotherapy-induced DNA damage.