R
Roger W. Wiseman
Researcher at National Institutes of Health
Publications - 76
Citations - 12417
Roger W. Wiseman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Tumor suppressor gene. The author has an hindex of 39, co-authored 69 publications receiving 12034 citations. Previous affiliations of Roger W. Wiseman include Myriad Genetics & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
Yoshio Miki,Jeff Swensen,Donna M Shattuck-Eidens,P. Andrew Futreal,Keith D Harshman,Sean V. Tavtigian,Qingyun Liu,Charles Cochran,L. Michelle Bennett,Wei Ding,Russell Bell,Judith Rosenthal,Charles E. Hussey,Thanh Tran,Melody McClure,Cheryl Frye,Tom Hattier,Robert Phelps,Astrid Haugen-Strano,Harold Katcher,Kazuko Yakumo,Zahra Gholami,Daniel Shaffer,Steven Stone,Steven Bayer,Christian Wray,Robert Bogden,Priya Dayananth,John R. Ward,Patricia N. Tonin,Steven A. Narod,Pam K. Bristow,Frank H. Norris,Leah M. Helvering,Paul Morrison,Paul Robert Rosteck,Mei Lai,J. Carl Barrett,Cathryn M. Lewis,Susan L. Neuhausen,Lisa A. Cannon-Albright,David E. Goldgar,Roger W. Wiseman,Alexander Kamb,Mark H. Skolnick +44 more
TL;DR: A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods.
Journal ArticleDOI
BRCA1 mutations in primary breast and ovarian carcinomas
P. Andrew Futreal,Qingyun Liu,Donna M Shattuck-Eidens,Charles Cochran,Keith D Harshman,Sean V. Tavtigian,L. Michelle Bennett,Astrid Haugen-Strano,Jeff Swensen,Yoshio Miki,Ken Eddington,Melody McClure,Cheryl Frye,Jane Weaver-Feldhaus,Wei Ding,Zahra Gholami,Peter Söderkvist,Lori A. Terry,Suresh C. Jhanwar,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Dennis G. Ballinger,J. Cari Barrett,Mark H. Skolnick,Mark H. Skolnick,Alexander Kamb,Roger W. Wiseman +27 more
TL;DR: Results suggest that mutation of BRCA1 may not be critical in the development of the majority of breast and ovarian cancers that arise in the absence of a mutant germline allele.
Journal ArticleDOI
Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22.
Lisa A. Cannon-Albright,David E. Goldgar,Laurence Meyer,Cathryn M. Lewis,David E. Anderson,Jane W. Fountain,Monika E. Hegi,Roger W. Wiseman,Elizabeth M. Petty,Allen E. Bale,Olufunmilayo I. Olopade,Manuel O. Diaz,David J. Kwiatkowski,Michael Piepkorn,John J. Zone,Mark H. Skolnick +15 more
TL;DR: Linkage analysis of Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22, previously implicated in homozygous deletions in melanoma tumors.
Journal Article
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.
Michele Harvey,Arthur T. Sands,Robert S. Weiss,Monika E. Hegi,Roger W. Wiseman,P. Pantazis,Beppino C. Giovanella,Michael A. Tainsky,Allan Bradley,Lawrence A. Donehower +9 more
TL;DR: It is concluded that the loss of p53 by itself is insufficient to confer immortality on a cell, but does confer a growth advantage, confirming that the absence of p 53 promotes genomic instability, which in turn may result in genetic alterations which directly produce immortality.
Journal ArticleDOI
BRCA2 mutations in primary breast and ovarian cancers
Johnathan M. Lancaster,Richard Wooster,Jonathon Mangion,Catherine M. Phelan,Catherine M. Phelan,Catherine M. Phelan,Charles Cochran,Curtis Gumbs,Sheila Seal,Rita Barfoot,N. Collins,Graham R. Bignell,Sandeep Patel,Rifat Hamoudi,Catharina Larsson,Roger W. Wiseman,Andrew Berchuck,J. Dirk Iglehart,Jeffrey R. Marks,Alan Ashworth,Michael R. Stratton,P. Andrew Futreal +21 more
TL;DR: The results suggest that BRCA2 is a very infrequent target for somatic inactivation in breast and ovarian carcinomas, similar to the results obtained torBRCAL.