R
Rogier W. Sanders
Researcher at University of Amsterdam
Publications - 332
Citations - 24796
Rogier W. Sanders is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 75, co-authored 278 publications receiving 19657 citations. Previous affiliations of Rogier W. Sanders include Scripps Research Institute & Cornell University.
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Journal ArticleDOI
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Philip J. M. Brouwer,Tom G. Caniels,Karlijn van der Straten,Jonne L. Snitselaar,Yoann Aldon,Sandhya Bangaru,Jonathan L. Torres,Nisreen M.A. Okba,Mathieu Claireaux,Gius Kerster,Arthur E. H. Bentlage,Marlies M. van Haaren,Denise Guerra,Judith A. Burger,Edith E. Schermer,Kirsten D. Verheul,Niels van der Velde,Alex van der Kooi,Jelle van Schooten,Mariëlle J. van Breemen,Tom P. L. Bijl,Kwinten Sliepen,Aafke Aartse,Aafke Aartse,Ronald Derking,Ilja Bontjer,Neeltje A. Kootstra,W. Joost Wiersinga,Gestur Vidarsson,Bart L. Haagmans,Andrew B. Ward,Godelieve J. de Bree,Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils +34 more
TL;DR: It is shown that the patients had strong immune responses against the viral spike protein, a complex that binds to receptors on the host cell, and monoclonal antibodies isolated here are promising candidates for COVID-19 treatment and prevention.
Journal ArticleDOI
A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies
Rogier W. Sanders,Rogier W. Sanders,Ronald Derking,Albert Cupo,Jean-Philippe Julien,Anila Yasmeen,Natalia de Val,Helen J. Kim,Claudia Blattner,Alba Torrents de la Peña,Jacob Korzun,Michael Golabek,Kevin de los Reyes,Thomas J. Ketas,Marit J. van Gils,C. Richter King,Ian A. Wilson,Andrew B. Ward,Per Johan Klasse,John P. Moore +19 more
TL;DR: The design and properties of soluble, cleaved SOSIP trimers based on the subtype A transmitted/founder strain, BG505, are described, which are highly stable and homogenous and closely resemble native virus spikes when visualized by negative stain electron microscopy (EM).
Journal ArticleDOI
Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Jean-Philippe Julien,Jean-Philippe Julien,Albert Cupo,Devin Sok,Devin Sok,Robyn L. Stanfield,Robyn L. Stanfield,Dmitry Lyumkis,Marc C. Deller,Per Johan Klasse,Dennis R. Burton,Rogier W. Sanders,John P. Moore,Andrew B. Ward,Andrew B. Ward,Ian A. Wilson +15 more
TL;DR: The crystal structure at 4.7 angstroms of a soluble, cleaved Env trimer that is stabilized and antigenically near-native in complex with a potent broadly neutralizing antibody, PGT122 is described.
Journal ArticleDOI
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
Robert Pejchal,Katie J. Doores,Katie J. Doores,Laura M. Walker,Reza Khayat,Po-Ssu Huang,Sheng-Kai Wang,Robyn L. Stanfield,Jean-Philippe Julien,Alejandra Ramos,Matthew Crispin,Rafael S. Depetris,Umesh Katpally,Andre Marozsan,Albert Cupo,Sebastien M. Maloveste,Yan Liu,Ryan McBride,Yukishige Ito,Rogier W. Sanders,Cassandra Ogohara,James C. Paulson,Ten Feizi,Christopher N. Scanlan,Chi-Huey Wong,John P. Moore,William C. Olson,Andrew B. Ward,Pascal Poignard,Pascal Poignard,William R. Schief,William R. Schief,Dennis R. Burton,Dennis R. Burton,Ian A. Wilson +34 more
TL;DR: The data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface.
Journal ArticleDOI
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer
Dmitry Lyumkis,Jean-Philippe Julien,Natalia de Val,Albert Cupo,Clinton S. Potter,Per Johan Klasse,Dennis R. Burton,Rogier W. Sanders,Rogier W. Sanders,John P. Moore,Bridget Carragher,Ian A. Wilson,Andrew B. Ward,Andrew B. Ward +13 more
TL;DR: A cryo–electron microscopy reconstruction and structural model of a cleaved, soluble Env trimer in complex with a CD4 binding site bnAb, PGV04 is presented, which reveals the spatial arrangement of Env components, including the V1/V2, V3, HR1, and HR2 domains, as well as shielding glycans.