R
Rohini Sidhu
Researcher at Washington University in St. Louis
Publications - 46
Citations - 3120
Rohini Sidhu is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cholesterol storage & NPC1. The author has an hindex of 25, co-authored 43 publications receiving 2532 citations.
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Journal ArticleDOI
Cholesterol Oxidation Products Are Sensitive and Specific Blood-Based Biomarkers for Niemann-Pick C1 Disease
Forbes D. Porter,David E. Scherrer,Michael H. Lanier,S. Joshua Langmade,Vasumathi Molugu,Sarah E. Gale,Dana Olzeski,Rohini Sidhu,Dennis J. Dietzen,Rao Fu,Christopher A. Wassif,Nicole M. Yanjanin,Steven P. Marso,John A. House,Charles H. Vite,Jean E. Schaffer,Daniel S. Ory +16 more
TL;DR: Blood concentrations of two related oxysterols molecules were almost 10 times higher in Niemann-Pick C1 patients than in age-matched healthy controls or those with other diseases such as atherosclerosis or diabetes, suggesting that the two oxysterol molecules are accurate diagnostic markers of early clinical disease and can be used not only to monitor disease progression but also to demonstrate drug efficacy.
Journal ArticleDOI
Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial
Daniel S. Ory,Elizabeth A. Ottinger,Nicole Y. Farhat,Kelly A. King,Xuntian Jiang,Lisa Weissfeld,Elizabeth Berry-Kravis,Cristin Davidson,Simona Bianconi,Lee Ann Keener,Ravichandran Rao,Ariane Soldatos,Rohini Sidhu,Kimberly A Walters,Xin Xu,Audrey Thurm,Beth Solomon,William J. Pavan,Bernardus Nicolaas Machielse,Mark L. Kao,Steven A. Silber,John C. McKew,Carmen C. Brewer,Charles H. Vite,Steven U. Walkley,Christopher P. Austin,Forbes D. Porter +26 more
TL;DR: This open-label, dose-escalation phase 1-2a study gave monthly intrathecal HPβCD to participants with NPC1 with neurological manifestation at the National Institutes of Health and evaluated Serum and CSF 24(S)-hydroxycholesterol (24[S]-HC), which serves as a biomarker of target engagement, andCSF protein biomarkers were evaluated.
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A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma
Xuntian Jiang,Rohini Sidhu,Forbes D. Porter,Nicole M. Yanjanin,Anneliese O. Speak,Danielle Taylor te Vruchte,Frances M. Platt,Hideji Fujiwara,David E. Scherrer,Jessie Zhang,Dennis J. Dietzen,Jean E. Schaffer,Daniel S. Ory +12 more
TL;DR: The development of a sensitive and specific LC-MS/MS method for quantifying 3β,5α,6β-triol and 7-KC human plasma after derivatization with N,N-dimethylglycine is described, offering for the first time a noninvasive, rapid, and highly sensitive method for diagnosis of NPC1 disease.
Journal ArticleDOI
Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration
Abdoulaye Sene,Aslam A. Khan,Douglas Cox,Rei E.I. Nakamura,Andrea Santeford,Bryan M. Kim,Rohini Sidhu,Michael D. Onken,J. William Harbour,Shira Hagbi-Levi,Itay Chowers,Peter A. Edwards,Ángel Baldán,John S. Parks,Daniel S. Ory,Rajendra S. Apte +15 more
TL;DR: It is demonstrated that abnormal polarization in older macrophages is caused by programmatic changes that lead to reduced expression of ATP binding cassette transporter ABCA1, and this findings provide an avenue for therapeutic modulation of macrophage function in common age-related diseases.
Journal ArticleDOI
Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress
Carlos I. Michel,Christopher L. Holley,Benjamin S. Scruggs,Rohini Sidhu,Rita T. Brookheart,Laura L. Listenberger,Mark A. Behlke,Daniel S. Ory,Jean E. Schaffer +8 more
TL;DR: It is shown that loss of three box C/D small nucleolar RNAs (snoRNAs) encoded in the ribosomal protein L13a (rpL13a) locus is sufficient to confer resistance to lipotoxic and oxidative stress in vitro and prevents the propagation of oxidative stressIn vivo.