Rohit Bhargava

TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.

TL;DR: Androgen receptor-targeted therapy in estrogen/progesterone receptor-negative tumors may provide an inexpensive alternative to usual high-dose chemotherapy with or without trastuzumab and suggest that these tumors together comprises the ‘molecular apocrine’ group described previously.

TL;DR: It is shown that tumour-associated monocytes and macrophages create a CSC niche through juxtacrine signalling with CSCs through upregulating the expression of CD90 and EphA4, which mediate the physical interactions of C SCs with TAMs by directly binding with their respective counter-receptors on these cells.

TL;DR: Mammaglobin is a more sensitive marker than GCDFP-15 for breast carcinoma; however, it lacks the specificity of GCD FP-15.

TL;DR: Although the Oncotype DX™ Recurrence Score holds potential, further validation of its independent value beyond that of histopathologic analysis is necessary before it can be implemented in clinical decision making.