Rokon Uddin

TL;DR: In this paper, a biosensing platform for the detection of proteins based on agglutination of aptamer coated magnetic nano-or microbeads is presented. But the authors focus on the low sample-to-answer time and portability of both detection instruments.

TL;DR: Results of a quantitative investigation of interactions between metformin and L-cysteine-copper complexes suggest that met formin could interact with biological copper, which plays a key role in mitochondrial function.

TL;DR: The concurrent/combined detection of these two common biomarkers in an automated microfluidic platform with integrated detection units and with a low sample-to-answer time is a significant step forward towards a low-cost, out-of-lab, and portable tool to detect multiple biomarkers of significantly different nature.

TL;DR: A novel biosensing platform for investigating the MOA of metformin using a magnetic microbead-based agglutination assay is presented which has allowed us to demonstrate for the first time the interaction between Cu and meetformin at clinically relevant low micromolar concentrations of the drug, thus suggesting a potential pathway of met formin’s blood-glucose lowering action.

TL;DR: In this article, a lab-on-a-disk (LAB) system was developed for retrieving different density layers from a liquid column by "overflowing" the layers sequentially using the pressure exerted by a density-gradient liquid.