R
Roland Berger
Researcher at Necker-Enfants Malades Hospital
Publications - 300
Citations - 19720
Roland Berger is an academic researcher from Necker-Enfants Malades Hospital. The author has contributed to research in topics: Chromosomal translocation & Gene. The author has an hindex of 66, co-authored 300 publications receiving 19187 citations. Previous affiliations of Roland Berger include Laboratory of Molecular Biology & French Institute of Health and Medical Research.
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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James,Valérie Ugo,Jean-Pierre Le Couedic,Judith Staerk,François Delhommeau,Catherine Lacout,Loïc Garçon,Hana Raslova,Roland Berger,Annelise Bennaceur-Griscelli,Jean-Luc Villeval,Stefan N. Constantinescu,Nicole Casadevall,William Vainchenker +13 more
TL;DR: A clonal and recurrent mutation in the JH2 pseudo-kinase domain of the Janus kinase 2 (JAK2) gene in most (> 80%) polycythaemia vera patients leads to constitutive tyrosine phosphorylation activity that promotes cytokine hypersensitivity and induces erythrocytosis in a mouse model.
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All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.
Sylvie Castaigne,Christine Chomienne,Marie Therese Daniel,Paola Ballerini,Roland Berger,Pierre Fenaux,Laurent Degos +6 more
TL;DR: The study confirms the major efficacy of all-trans RA in M3, even in relapsing patients, and shows that complete remissions were obtained without bone marrow (BM) hypoplasia and by a differentiation process.
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NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
TL;DR: In vitro and in vivo studies suggest that all-trans retinoic acid (RA) treatment restores cell maturation, and the first permanent cell line with t(15;17), derived from the marrow of a patient with APL in relapse is isolated.
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A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia
Virginie Lacronique,Virginie Lacronique,Anthony Boureux,Anthony Boureux,Véronique Della Valle,Véronique Della Valle,Hélène Poirel,Hélène Poirel,Christine Tran Quang,Christine Tran Quang,M. Mauchauffe,M. Mauchauffe,Christian Berthou,Christian Berthou,Michel Lessard,Michel Lessard,Roland Berger,Roland Berger,Jacques Ghysdael,Jacques Ghysdael,Olivier A. Bernard,Olivier A. Bernard +21 more
TL;DR: TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3-dependent Ba/F3 hematopoietic cell line.
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The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.
Serge Romana,M. Mauchauffe,M Le Coniat,I Chumakov,D Le Paslier,Roland Berger,Olivier Bernard +6 more
TL;DR: This translocation fused two genes, tel and AML1, that have previously been described in chromosomal translocations specific for myeloid malignancies, that belong to an increasing number of human genes that are involved in a variety of hematopoietic malignant disorders and can be rearranged with numerous partners.