R
Roland S. Rogers
Researcher at G. D. Searle & Company
Publications - 11
Citations - 3327
Roland S. Rogers is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Moiety & Sulfone. The author has an hindex of 8, co-authored 11 publications receiving 3198 citations.
Papers
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Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
John J. Talley,David L. Brown,Jeffery S. Carter,Matthew J. Graneto,Carol M. Koboldt,Jaime L. Masferrer,William E. Perkins,Roland S. Rogers,Alexander F. Shaffer,Yan Y. Zhang,Ben S. Zweifel,Karen Seibert +11 more
Patent
Substituted isoxazoles for the treatment of inflammation
David L. Brown,Jeffery S. Carter,Paul W. Collins,Matthew J. Graneto,Srinivasan Nagarajan,Richard Partis,Roland S. Rogers,Karen Seibert,Stealey Michael A,John J. Talley,Richard M. Weier,Xiangdong Xu +11 more
TL;DR: A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders as discussed by the authors, which are defined by Formula (III) whrein R7 is selected from hydroxyl, lower alkyl, carboxyl, halo, lower carboxyalky, lower alkoxy carbonyl, lower aralkyl; and wherein R8 is one or more radicals independently selected from Hydrido, lower Alkylsulfinyl, lower ALkyL, cyano, caroxynine, Carboxyl and Car
Patent
Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
John J. Talley,Thomas D. Penning,Paul W. Collins,Donald J. Rogier,James W. Malecha,Julie M. Miyashiro,Stephen R. Bertenshaw,Ish K. Khanna,Matthew J. Graneto,Roland S. Rogers,Jeffery S. Carter,Stephen H. Docter,Stella S. Yu +12 more
TL;DR: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders in this paper, where the compounds of particular interest are defined by formula (II).
Patent
Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents
John J. Talley,Stephen R. Bertenshaw,Paul W. Collins,Thomas D. Penning,David B. Reitz,Roland S. Rogers +5 more
TL;DR: A class of 3,4-diaryl substitued thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders as discussed by the authors.