R
Rolando Rolesi
Researcher at Catholic University of the Sacred Heart
Publications - 27
Citations - 927
Rolando Rolesi is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Hearing loss & Oxidative stress. The author has an hindex of 13, co-authored 23 publications receiving 646 citations. Previous affiliations of Rolando Rolesi include Agostino Gemelli University Polyclinic.
Papers
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Journal ArticleDOI
Noise-induced hearing loss (NIHL) as a target of oxidative stress-mediated damage: cochlear and cortical responses after an increase in antioxidant defense.
Anna Rita Fetoni,Paola De Bartolo,Sara Letizia Maria Eramo,Rolando Rolesi,Fabiola Paciello,Christian Bergamini,Romana Fato,Gaetano Paludetti,Laura Petrosini,Diana Troiani +9 more
TL;DR: Findings indicate that antioxidant treatment restores auditory cortical neuronal morphology and hearing function by reducing the noise-induced redox imbalance in the cochlea and the deafferentation effects upstream the acoustic pathway.
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Targeting dysregulation of redox homeostasis in noise-induced hearing loss: Oxidative stress and ROS signaling.
TL;DR: This review discusses the dual function of ROS to both promote cell damage and cell adaptive responses (ROS signaling) in the cochlea undergoing a stressful condition such as noise exposure, and focuses on animal models of noise-induced hearing loss.
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Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling.
Anna Rita Fetoni,Fabiola Paciello,Daniele Mezzogori,Rolando Rolesi,Sara Letizia Maria Eramo,Gaetano Paludetti,Diana Troiani +6 more
TL;DR: This study demonstrates that curcumin attenuates all stages of tumour progression and, by targeting pSTAT3 and Nrf-2 signalling pathways, provides chemosensitisation to cisplatin in vitro and protection from its ototoxic adverse effects in vivo.
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Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea.
Anna Rita Fetoni,Fabiola Paciello,Rolando Rolesi,Sara Letizia Maria Eramo,Cesare Mancuso,Diana Troiani,Gaetano Paludetti +6 more
TL;DR: The herb-derived phenol rosmarinic acid (RA) attenuates noise-induced hearing loss, reducing threshold shift, and promotes hair cell survival, and enhances the endogenous antioxidant defenses, as shown by decreased superoxide production, reduced expression of 4-HNE, and up-regulation of SODs.
Journal Article
Infant hearing loss: from diagnosis to therapy Official Report of XXI Conference of Italian Society of Pediatric Otorhinolaryngology
Gaetano Paludetti,Guido Conti,W. Di Nardo,E. De Corso,Rolando Rolesi,Pasqualina Maria Picciotti,Anna Rita Fetoni +6 more
TL;DR: In this paper, a review addresses the innovative evidences on aetiology and management of deafness in children, including universal neonatal screening, advances in genetic diagnosis and the contribution of neuroimaging.