R
Rolf Boelens
Researcher at Utrecht University
Publications - 353
Citations - 21166
Rolf Boelens is an academic researcher from Utrecht University. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Protein structure. The author has an hindex of 71, co-authored 353 publications receiving 19940 citations. Previous affiliations of Rolf Boelens include École Normale Supérieure & Temple University.
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HADDOCK: a protein-protein docking approach based on biochemical or biophysical information.
TL;DR: An approach called HADDOCK (High Ambiguity Driven protein-protein Docking) that makes use of biochemical and/or biophysical interaction data such as chemical shift perturbation data resulting from NMR titration experiments or mutagenesis data to drive the docking process.
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Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
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New insights into the structure and composition of technical lignins: a comparative characterisation study
Sandra Constant,Hans Wienk,Augustinus Emmanuel Frissen,Peter de Peinder,Rolf Boelens,Daan S. van Es,R.J.H. Grisel,Bert M. Weckhuysen,Wouter J. J. Huijgen,Richard J.A. Gosselink,Pieter C. A. Bruijnincx +10 more
TL;DR: In this article, a comparison of nine SEC methods, including the first analysis of lignins with commercial alkaline SEC columns, showed molar masses to vary considerably, allowing some recommendations to be made.
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Solution structure of the glucocorticoid receptor DNA-binding domain
Torleif Härd,Edwin Kellenbach,Rolf Boelens,Bonnie A. Maler,Karin Dahlman,Leonard P. Freedman,Leonard P. Freedman,Jan Carlstedt-Duke,Keith R. Yamamoto,Jan-Åke Gustafsson,Robert Kaptein +10 more
TL;DR: A model of the dimeric complex between the DBD and the glucocorticoid response element is proposed, consistent with previous results indicating that specific amino acid residues of the D BD are involved in protein-DNA and protein-protein interactions.
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Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes
Charalampos G. Kalodimos,Nikolaos Biris,Alexandre M. J. J. Bonvin,Marc M. Levandoski,Marc Guennuegues,Rolf Boelens,Robert Kaptein +6 more
TL;DR: The solution structure and dynamics of the complex of a dimeric lac repressor DNA binding domain with nonspecific DNA is reported, showing that the protein-DNA interface of the nonspecial complex is flexible on biologically relevant time scales that may assist in the rapid and efficient finding of the target site.