R
Rolf Holle
Researcher at Heidelberg University
Publications - 229
Citations - 14350
Rolf Holle is an academic researcher from Heidelberg University. The author has contributed to research in topics: Population & Type 2 diabetes. The author has an hindex of 58, co-authored 224 publications receiving 13099 citations.
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Journal ArticleDOI
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Cornelius A. Rietveld,Sarah E. Medland,Jaime Derringer,Jian Yang,Tõnu Esko,Nicolas W. Martin,Nicolas W. Martin,Harm-Jan Westra,Konstantin Shakhbazov,Abdel Abdellaoui,Arpana Agrawal,Eva Albrecht,Behrooz Z. Alizadeh,Najaf Amin,John Barnard,Sebastian E. Baumeister,Kelly S. Benke,Lawrence F. Bielak,Jeffrey A. Boatman,Patricia A. Boyle,Gail Davies,Christiaan de Leeuw,Niina Eklund,Niina Eklund,Daniel S. Evans,Rudolf Ferhmann,Krista Fischer,Christian Gieger,Håkon K. Gjessing,Sara Hägg,Sara Hägg,Jennifer R. Harris,Caroline Hayward,Christina Holzapfel,Carla A. Ibrahim-Verbaas,Erik Ingelsson,Erik Ingelsson,Bo Jacobsson,Bo Jacobsson,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Juha Karjalainen,Ivana Kolcic,Kati Kristiansson,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Jari Lahti,Sang Hong Lee,Peng Lin,Penelope A. Lind,Yongmei Liu,Kurt Lohman,Marisa Loitfelder,George McMahon,Pedro Marques Vidal,Osorio Meirelles,Lili Milani,Ronny Myhre,Marja-Liisa Nuotio,Marja-Liisa Nuotio,Christopher Oldmeadow,Katja Petrovic,Wouter J. Peyrot,Ozren Polasek,Lydia Quaye,Eva Reinmaa,John P. Rice,Thais S. Rizzi,Helena Schmidt,Reinhold Schmidt,Albert V. Smith,Jennifer A. Smith,Toshiko Tanaka,Antonio Terracciano,Antonio Terracciano,Matthijs J. H. M. van der Loos,Veronique Vitart,Henry Völzke,Jürgen Wellmann,Lei Yu,Wei Zhao,Jüri Allik,John Attia,Stefania Bandinelli,François Bastardot,Jonathan P. Beauchamp,David A. Bennett,Klaus Berger,Laura J. Bierut,Dorret I. Boomsma,Ute Bültmann,Harry Campbell,Christopher F. Chabris,Lynn Cherkas,Mina K. Chung,Francesco Cucca,Francesco Cucca,Mariza de Andrade,Philip L. De Jager,Jan-Emmanuel De Neve,Jan-Emmanuel De Neve,Ian J. Deary,George Dedoussis,Panos Deloukas,Maria Dimitriou,Guoný Eiríksdóttir,Martin F. Elderson,Johan G. Eriksson,David M. Evans,Jessica D. Faul,Luigi Ferrucci,Melissa E. Garcia,Henrik Grönberg,Vilmundur Guonason,Per Hall,Juliette Harris,Tamara B. Harris,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,Wolfgang Hoffmann,Adriaan Hofman,Rolf Holle,Elizabeth G. Holliday,Jouke-Jan Hottenga,William G. Iacono,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Robert M. Kirkpatrick,Matthew Kowgier,Antti Latvala,Antti Latvala,Lenore J. Launer,Debbie A Lawlor,Terho Lehtimäki,Jingmei Li,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Pamela A. F. Madden,Patrik K. E. Magnusson,Tomi E. Mäkinen,Marco Masala,Matt McGue,Andres Metspalu,Andreas Mielck,Michael B. Miller,Grant W. Montgomery,Sutapa Mukherjee,Sutapa Mukherjee,Dale R. Nyholt,Ben A. Oostra,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Patricia A. Peyser,Martin Preisig,Katri Räikkönen,Olli T. Raitakari,Anu Realo,Susan M. Ring,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Antti-Pekka Sarin,David Schlessinger,Rodney J. Scott,Harold Snieder,Beate St Pourcain,John M. Starr,Jae Hoon Sul,Ida Surakka,Ida Surakka,Rauli Svento,Alexander Teumer,Henning Tiemeier,Frank J. A. van Rooij,David R. Van Wagoner,Erkki Vartiainen,Jorma Viikari,Peter Vollenweider,Judith M. Vonk,Gérard Waeber,David R. Weir,H.-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Dalton Conley,George Davey-Smith,Lude Franke,Patrick J. F. Groenen,Albert Hofman,Magnus Johannesson,Sharon L.R. Kardia,Robert F. Krueger,David Laibson,Nicholas G. Martin,Michelle N. Meyer,Michelle N. Meyer,Danielle Posthuma,Danielle Posthuma,Roy Thurik,Nicholas J. Timpson,André G. Uitterlinden,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,David Cesarini,David Cesarini,Philipp Koellinger +230 more
TL;DR: In this article, a genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490 individuals, and three independent SNPs are genome wide significant (rs9320913, rs11584700, rs4851266).
Journal ArticleDOI
DNA methylation-based measures of biological age: meta-analysis predicting time to death
Brian H. Chen,Riccardo E. Marioni,Riccardo E. Marioni,Elena Colicino,Marjolein J. Peters,Cavin K. Ward-Caviness,Pei-Chien Tsai,Nicholas S. Roetker,Allan C. Just,Ellen W. Demerath,Weihua Guan,Jan Bressler,Myriam Fornage,Myriam Fornage,Stephanie A. Studenski,Amy R. Vandiver,Ann Zenobia Moore,Toshiko Tanaka,Douglas P. Kiel,Liming Liang,Pantel S. Vokonas,Joel Schwartz,Kathryn L. Lunetta,Kathryn L. Lunetta,Joanne M. Murabito,Joanne M. Murabito,Stefania Bandinelli,Dena G. Hernandez,David Melzer,Mike A. Nalls,Luke C. Pilling,Timothy Ryan Price,Andrew B. Singleton,Christian Gieger,Rolf Holle,Anja Kretschmer,Florian Kronenberg,Sonja Kunze,Jakob Linseisen,Christine Meisinger,Wolfgang Rathmann,Melanie Waldenberger,Peter M. Visscher,Peter M. Visscher,Sonia Shah,Naomi R. Wray,Allan F. McRae,Oscar H. Franco,Albert Hofman,Albert Hofman,André G. Uitterlinden,Devin Absher,Themistocles L. Assimes,Morgan E. Levine,Ake T. Lu,Philip S. Tsao,Philip S. Tsao,Lifang Hou,JoAnn E. Manson,Cara L. Carty,Andrea Z. LaCroix,Alexander P. Reiner,Alexander P. Reiner,Tim D. Spector,Andrew P. Feinberg,Daniel Levy,Andrea A. Baccarelli,Andrea A. Baccarelli,Joyce B. J. van Meurs,Jordana T. Bell,Annette Peters,Ian J. Deary,James S. Pankow,Luigi Ferrucci,Steve Horvath +74 more
TL;DR: Evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors is strengthened and estimates that incorporate information on blood cell counts lead to highly significant associations with all- Cause mortality are demonstrated.
Journal ArticleDOI
KORA--a research platform for population based health research.
TL;DR: The KORA infrastructure, aspects of data management and quality control, and the concept of cooperative research are presented.
Journal ArticleDOI
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
Cecilia M. Lindgren,Iris M. Heid,Joshua C. Randall,Claudia Lamina,Valgerdur Steinthorsdottir,Lu Qi,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Gudmar Thorleifsson,Cristen J. Willer,Blanca M. Herrera,Anne U. Jackson,Noha Lim,Paul Scheet,Nicole Soranzo,Nicole Soranzo,Najaf Amin,Yurii S. Aulchenko,John C. Chambers,Alexander W. Drong,Jia N.an Luan,Helen N. Lyon,Helen N. Lyon,Fernando Rivadeneira,Serena Sanna,Nicholas J. Timpson,M. Carola Zillikens,Hua Zhao Jing,Peter Almgren,Stefania Bandinelli,Amanda J. Bennett,Richard N. Bergman,Lori L. Bonnycastle,Suzannah Bumpstead,Stephen J. Chanock,Lynn Cherkas,Peter S. Chines,Lachlan J. M. Coin,Cyrus Cooper,Gabriel Crawford,Angela Doering,Anna F. Dominiczak,Alex S. F. Doney,Shah Ebrahim,Paul Elliott,Michael R. Erdos,Karol Estrada,Luigi Ferrucci,Guido Fischer,Nita G. Forouhi,Christian Gieger,Harald Grallert,Christopher J. Groves,Scott M. Grundy,Candace Guiducci,David Hadley,Anders Hamsten,Aki S. Havulinna,Albert Hofman,Rolf Holle,John W. Holloway,Thomas Illig,Bo Isomaa,Leonie C. Jacobs,Karen A. Jameson,Pekka Jousilahti,Fredrik Karpe,Johanna Kuusisto,Jaana Laitinen,G. Mark Lathrop,Debbie A Lawlor,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Mario A. Morken,Andrew P. Morris,Patricia B. Munroe,Narisu Narisu,Anna Nordström,Peter Nordström,Ben A. Oostra,Colin N. A. Palmer,Felicity Payne,John F. Peden,Inga Prokopenko,Frida Renström,Aimo Ruokonen,Veikko Salomaa,Manjinder S. Sandhu,Manjinder S. Sandhu,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Kijoung Song,Xin Yuan,Heather M. Stringham,Amy J. Swift,Tiinamaija Tuomi,Manuela Uda,Peter Vollenweider,Gérard Waeber,Chris Wallace,G. Bragi Walters,Michael N. Weedon,Jacqueline C.M. Witteman,Cuilin Zhang,Weihua Zhang,Mark J. Caulfield,Francis S. Collins,George Davey Smith,Ian N. M. Day,Paul W. Franks,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Augustine Kong,Jaspal S. Kooner,Markku Laakso,Edward G. Lakatta,Vincent Mooser,Andrew D. Morris,Leena Peltonen,Leena Peltonen,Nilesh J. Samani,Tim D. Spector,David P. Strachan,Toshiko Tanaka,Toshiko Tanaka,Jaakko Tuomilehto,André G. Uitterlinden,Cornelia M. van Duijn,Nicholas J. Wareham,Hugh Watkins,Dawn M. Waterworth,Michael Boehnke,Panos Deloukas,Leif Groop,Leif Groop,David J. Hunter,David J. Hunter,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,David Schlessinger,H.-Erich Wichmann,Timothy M. Frayling,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos,Kari Stefansson,Kari Stefansson,Karen L. Mohlke,Inês Barroso,Mark I. McCarthy +155 more
TL;DR: By focusing on anthropometric measures of central obesity and fat distribution, a meta-analysis of 16 genome-wide association studies informative for adult waist circumference and waist–hip ratio identified three loci implicated in the regulation of human adiposity.
Journal ArticleDOI
Acute stroke: usefulness of early CT findings before thrombolytic therapy.
R. von Kummer,K L Allen,Rolf Holle,Luigi Bozzao,Stefano Bastianello,Claude Manelfe,Erich Bluhmki,Peter A. Ringleb,Dieter Meier,Werner Hacke +9 more
TL;DR: The response to rt-PA in patients with ischemic stroke can be predicted on the basis of initial CT findings of the extent of parenchymal hypoattenuation in the territory of the middle cerebral artery.