R
Rolf Zetterström
Researcher at Karolinska University Hospital
Publications - 174
Citations - 8110
Rolf Zetterström is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Newborn screening & Population. The author has an hindex of 35, co-authored 166 publications receiving 7555 citations. Previous affiliations of Rolf Zetterström include Ludwig Institute for Cancer Research & Science for Life Laboratory.
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Journal ArticleDOI
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Steven A. Kliewer,John T. Moore,Laura E. Wade,Jeff L. Staudinger,Michael A. Watson,Stacey A. Jones,David D. McKee,Beverly B. Oliver,Timothy M. Willson,Rolf Zetterström,Thomas Perlmann,Jürgen M. Lehmann +11 more
TL;DR: The results provide evidence for the existence of a novel steroid hormone signaling pathway with potential implications in the regulation of steroid hormone and sterol homeostasis and the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo.
Journal ArticleDOI
Dopamine neuron agenesis in Nurr1-deficient mice.
Rolf Zetterström,Ludmila Solomin,Ludmila Solomin,Ludmila Solomin,Lottie Jansson,Lottie Jansson,Lottie Jansson,B. Hoffer,B. Hoffer,B. Hoffer,Lars Olson,Lars Olson,Lars Olson,Thomas Perlmann,Thomas Perlmann,Thomas Perlmann +15 more
TL;DR: Results suggest that putative Nurr1 ligands may be useful for treatment of Parkinson's disease and other disorders of midbrain dopamine circuitry.
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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
Alexander Mata de Urquiza,Suya Liu,Maria Sjöberg,Rolf Zetterström,William J. Griffiths,Jan Sjövall,Thomas Perlmann +6 more
TL;DR: DHA, a long-chain polyunsaturated fatty acid that is highly enriched in the adult mammalian brain, is identified as a factor in brain tissue from adult mice that activates RXR in cell-based assays, suggesting that DHA may influence neural function through activation of an RXR signaling pathway.
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Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system.
TL;DR: The spatiotemporal distribution of Nurr1 and NGFI-B mRNAs suggests that these transcription factors are involved in the development and maturation of specific sets of CNS neurons, implying one of these functions may be to control gene regulatory events important for development and function of those neurons that degenerate in patients with Parkinson's disease.
Journal ArticleDOI
Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid.
Rolf Zetterström,Eva Lindqvist,A Mata de Urquiza,Andreas Tomac,Ulf Eriksson,Thomas Perlmann,Lars Olson +6 more
TL;DR: The specific expression pattern ofretinoid‐binding proteins and nuclear retinoid receptors as well as the presence of RA in striatum suggests that retinoids are important in many brain structures and emphasizes a role for retinoidal in gene regulatory events in postnatal and adult striatum.